The invention relates to a pinaverium bromide synthesis method. Cheap and easily available morpholine as a raw material and an acylating agent undergo a reaction to produce a novel intermediate and pinaverium bromide is synthesized from the intermediate under mild conditions. Raw material reaction is complete, side reaction is less, the pinaverium bromide has treatment cis-isomeride content greater than or equal to 99% and trans-isomer content less than or equal to 1%, and product cis-isomer content is greatly improved.
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(2018/11/04)
Synthesis and comparative pharmacology of quaternary ammonium derivatives of 6,6 dimethylnorpinane: spasmolytic activity
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Baronnet,Foussard Blanpin,Bretaudeau,Hubert
p. 182 - 187
(2007/10/06)
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