Synthesis of spirocyclic σ1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability
Several 3H-spiro[[2]benzofuran-1,4′-piperidines] bearing a p-fluorobenzyl residue at the N-atom and various substituents in position 3 of the benzofuran system were synthesized. The crucial reaction steps are the addition of a lithiated benzaldehyde deriv
Gro?e Maestrup, Eva,Wiese, Christian,Schepmann, Dirk,Hiller, Achim,Fischer, Steffen,Scheunemann, Matthias,Brust, Peter,Wünsch, Bernhard
experimental part
p. 3630 - 3641
(2009/10/10)
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