Enzymes in organic chemistry, Part 4: Enantioselective hydrolysis of 1-acyloxy(aryl)methyl- and 1-acyloxy(heteroaryl)methylphosphonates with lipases from Aspergillus niger and Rhizopus oryzae. A comparative study
Racemic 1-acyloxy(aryl)methyl- and 1-acyloxy(heteroaryl)methylphosphonates (+)-4 are prepared and tested for kinetic resolution by lipases AP 6 and FAP 15. Both enzymes proved to be useful in terms of broadness of application, reaction rate and enantiomer
Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-β-lactamases
Although commercialized inhibitors of active site serine β-lactamases are currently used in coadministration with antibiotic therapy, no clinically useful inhibitors of metallo-β-lactamases (MBLs) have yet been discovered. In this paper, we investigated t