- Synthesis of 15R-PGD2: A potential DP2 receptor agonist
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The first total synthesis of 15R-PGD2 3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE 2. 15R-PGD2, a potential DP2 receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.
- Kim, Seongjin,Bellone, Sophie,Maxey, Kirk M.,Powell, William S.,Lee, Gue-Jae,Rokach, Joshua
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p. 1873 - 1876
(2007/10/03)
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- Preparation of ent-prostaglandin E2
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The enantiomeric prostaglandins, exemplified by ent-PGE2, are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE2, it was necessary to prepare it by total sy
- Taber, Douglass F,Jiang, Qin
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p. 5991 - 5994
(2007/10/03)
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- Racemic fluoro-substituted PGF2 α analogs
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This invention is racemic PGE2, racemic PGF2α, racemic PGF2β, racemic PGA2, racemic PGB2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibiton of platelet aggregation, increase of nasal patency, abortion, and wound healing.
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- Racemic prostaglandins of the 2-series and analogs thereof
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This invention is racemic PGE2, racemic PGF2α, racemic PGF2β , racemic PGA2, racemic PGB2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, abortion, and wound healing.
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- Racemic prostaglandins of the 2-series and analogs thereof
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This invention is racemic PGE 2, racemic PGF 2 α, racemic PGF 2 β, racemic PGA 2, racemic PGB 2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, abortion, and wound healing.
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- Enzymatic preparation and purification of prostaglandin E2.
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An enzymatic system has been developed for the production of prostaglandin E(2) (PGE(2)) from arachidonic acid by extracts of sheep seminal vesicular glands. The presence of glutathione insures high yields. A new procedure for the purification of PGE(2) was also developed, based on the dialysis of the biosynthesized product at pH 8 and extraction of the dialysate at pH 3 with chloroform. This procedure routinely gives yields of PGE(2) of 25-37% (from arachidonic acid) with a purity of 90-100%. Additional analytical proof of the identity of PGE(2) was provided by physicochemical characteristics of the crystalline thiosemicarbazide derivative, which can be readily prepared under mild conditions.
- Lapidus,Grant,Alburn
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p. 371 - 373
(2007/10/16)
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