- Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS
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This article had studied the thermal characterization of the raw material and different fluconazole crystals, obtained through recrystallization with different solvents using thermoanalytical techniques (TG, DTA, DSC-50, DSC Photovisual, DSC-60) and Pyr-GC/MS. The results confirmed that the fluconazole volatilizes without decomposition until 250 °C. Pyr-GC/MS showed hexachlorobenzene like impurities in fluconazole raw material.
- Moura, Elisana Afonso,Correia, Lidiane Pinto,Pinto, Marcia Ferraz,Procopio, Jose Valdilanio Virgulino,De Souza, Fabio Santos,MacEdo, Rui Oliveira
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p. 289 - 293
(2010/08/04)
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