Characterization of oxalic acid derivatives as new metabolites of metamizol (dipyrone) in incubated hen's egg and human
Metamizol (dipyrone, 1), a widely used drug with effective analgesic and antispasmodic properties, shows severe side effects like agranulocytosis and anaphylactic shock reactions, the reasons of which are not known until today. After oral administration 1
Wessel, Julia C.,Matyja, Magdalena,Neugebauer, Michael,Kiefer, Heiko,Daldrup, Thomas,Tarbah, Fuad A.,Weber, Horst
Oxalylhydrazides as oxidation products of analgesic pyrazolinones
In contrast to antipyrine (1a) and isopropylantipyrine (1b) the amino-substituted pyrazolinones 4-aminoantipyrine (1d), 4-methylaminoantipyrine (1e), 4-isopropylaminoantipyrine (1f) and dipyrone (1g) as well as 4-hydroxyantipyrine (1e) can be cleaved into
Weber,Bresser
p. 152 - 155
(2007/10/03)
Ring Opening of 3(2H)-Pyrazolones by Oxidation with Periodate
In contrast to the aminopyrazolones 1 the pyrazolones 3 and 5 are stable against singlet oxygen.However, no difference is observed in reaction of the title compounds 1, 3 and 5 with sodium metaperiodate forming the oxidation products 2, 4 and 6, respectively.The (1)H- and (13)C-nmr-spectra of 4 as well as those of 2 are complex due to the existence of rotameric isomers at room temperature.
Weber, Horst,Wollenberg, Eva
p. 551 - 553
(2007/10/02)
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