Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates
Herein we describe a general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions. The reduction method is suitable for an array of structural motifs derived from tertiary alcohols that bear diverse functional groups, including the synthesis of a key intermediate en route to estrone.
Ye, Yang,Ma, Guobin,Yao, Ken,Gong, Hegui
supporting information
p. 1625 - 1628
(2021/01/18)
Radical deoxygenation of hydroxyl groups via phosphites
A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with (n-Bu)3SnH/AIBN in refluxing benzene cleanly produces the deoxygenation product of the original alcohol. Copyright
Zhang, Liming,Koreeda, Masato
p. 13190 - 13191
(2007/10/03)
Steroids and sex hormones. Part 262. The radical induced stannane reduction of selenoesters and selenocarbonates: A new method for the degradation of carboxylic acids to nor-alkanes and for desoxygenation of alcohols to alkanes
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Pfenninger,Heuberger,Graf
p. 2328 - 2337
(2007/10/02)
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