- Direct Transformation of Tetrafluoroethylene to Trifluorovinylzinc via sp2C-F Bond Activation
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Trifluorovinylzinc is a common synthetic intermediate for trifluorovinyl derivatives, including α,β,β-trifluorostyrenes and hexafluorobutadiene. Here, we report a novel synthetic approach for the formation of trifluorovinylzinc chloride via a C-F bond activation of tetrafluoroethylene (TFE), which is an industrially cost-effective bulk feedstock with a negligible GWP. The present system provides a practical synthetic route to various trifluorovinyl derivatives with very low energy consumption.
- Kikushima, Kotaro,Etou, Yuusuke,Kamura, Ryohei,Takeda, Ippei,Ito, Hideki,Ohashi, Masato,Ogoshi, Sensuke
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supporting information
p. 8167 - 8172
(2020/11/02)
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- SYNTHESIS OF PERFLUOROACRYLIC ACID FROM 3-HYDROTETRAFLUOROPROPANOL
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Perfluoroacrylic acid 1a was prepared from tetrafluoropropanol-1 2 by reaction of an alkyl lithium yielding trifluoroacrylic alcohol 3, followed by oxidation of the latter with potassium permanganate, after protection of the double bond.
- Nguyen, T.,Wakselman, C.
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