- IMINO-UREA DERIVATIVES
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The present invention relates to the field of medicines, and in particular to an imino-urea derivative containing a furan structure and a composition thereof. The derivative and the composition thereof can be used in the manufacture of a medicament for treating a disease pathologically characterized by indoleamine 2,3-dioxygenase-mediated tryptophan metabolic pathway. The present invention also relates to a method for preparing the derivative and an intermediate thereof.
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Paragraph 0267-0268
(2020/11/30)
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- AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS
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The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
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Page/Page column 50-51
(2009/06/27)
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- Possible Anthelmintic Agents: Syntheses of 1,3-Disubstituted 1,2,3,4-Tetrahydro-9H-pyridoindoles and 6,8-Disubstituted 7,8,9,14b-Tetrahydro-14H-quinazolinopyridoindoles
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Pictet-Spengler reaction of tryptophan methyl ester with aromatic and heterocyclic aldehydes gives 1-substituted 3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyridoindoles (1 - 9).Ring closure of 1-(o-aminophenyl)-3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyridoindole (26) or its hydrazide (28) with N-methoxycarbonyl-S-methylisothiourea gives 6,8-disubstituted 7,8,9,14b-tetrahydro-14H-quinazolinopyridoindoles (34 and 29, respectively).The former class of compounds exhibit activity (60 - 86percent) of worm clearance against A. ceylanicum in hamsters whilea member of the latter class of compounds (34) exhibits 100percent of activity only against H. nana at 250 mg/kg in mice.Other compounds which exhibit worm clearance of less than 50percent have not been reported here.
- Kumar, Shiv,Roy, Jalpana,Seth, M.,Bhaduri, A. P.
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- Anthelmintic pyridine and thiazole substituted benzimidazole carbamates
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Compounds represented by the formula STR1 wherein R is STR2 R1 is 2-pyridyl, 3-pyridyl, 4-pyridyl or 2-thiazyl, R2 is lower alkyl and n is 1 or 2, And acid addition salts of the compounds wherein R1 is 2-pyridyl, 3-pyridyl or 4-pyridyl are disclosed as useful as anthelmintics against a broad spectrum of helminths. Processes for making the active compounds and novel intermediates useful therein are also disclosed.
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- Allophanimidate herbicides
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Allophanimidates and carbamates of the formulas EQU1 where R1 is hydrogen or alkyl; R2 is alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, benzyl or phenyl optionally substituted; R3 is SR4 or OR4/sub
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- 1,3,5-Triazinediones
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1,3,5-Triazinediones of the formula SPC1 Wherein X1, X2, R1, R2 and R3 are as hereinafter defined, are useful for the selective control of weeds in crops, e.g., corn. Many are also useful for altering plant flowering and plant sexual reproduction. Exemplary of the class of compounds are 3-isopropyl-6-methylthio-s-triazine-2,4(1H,3H)-dione, 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H)-dione.
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- Herbicidal triazines
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Compounds of the formula: SPC1 Wherein X is oxygen or sulfur; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylmethyl, cycloalkenylmethyl, bicycloalkyl, bicycloalkenyl, bicycloalkylmethyl, bicycloalkenylmethyl, phenyl, substituted alkyl, substituted cycloalkyl, or substituted phenyl; R2 is hydrogen or alkyl; R3 is H, methyl, or ethyl; and R4 is alkyl, alkenyl, alkynyl, or methoxy; and the salts with bases of those compounds wherein R2 is hydrogen, are useful as herbicides. A preferred compound is 1-methyl-3-cyclohexyl-6-dimethylamino-s-triazine-2,4(1H,3H)-dione.
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- Methods for increasing crop yields
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Methods for increasing the yield of crops comprising applying thereto an allophanimidate such as methyl 4-(p-chlorophenyl)-N-methoxycarbonylallo-phanimidate or methyl 4-(p-chlorophenyl)-N-methylthio-carbonylallophanimidate. A preferred use of this inventi
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- Methods for increasing rice crop yields
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A method for increasing the yield of rice crops involving application of an s-triazinedione such as 3-(4-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H)-dione to the seed, seedlings, or soil in which the seed or seedlings are planted.
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