- A process for preparing 2 - bromo - 5 - fluoro-toluene method
-
The invention discloses a method for preparing 2-bromine-5-fluorobenzotrifluoride. According to the preparation method, fluorobenzotrifluoride serves as a raw material, under the condition of concentrated sulfuric acid and composite catalysts, bromine is stirred and added dropwise, and 2-bromine-5-fluorobenzotrifluoride is obtained after separation and purification. The yield reaches over 91.1%, the reaction conversion rate is larger than 99%, and selectivity is 92-95%. The raw material applied in the reaction process is convenient to purchase, production cost is low, waste acid obtained in the reaction process can be recycled, post-processing is easy, and the whole technology does not generate a large amount of wastewater containing salt and organic matter. Economic benefits and social benefits are good.
- -
-
Paragraph 0029
(2017/08/25)
-
- PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS
-
Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.
- -
-
Paragraph 0163; 0164
(2013/03/26)
-
- PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS
-
Disclosed are pyrimidine derivatives for use as sphingosine 1- phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.
- -
-
Page/Page column 25-26
(2011/10/10)
-
- COMPOUNDS
-
The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
- -
-
Page/Page column 26
(2011/11/12)
-
- COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS
-
Compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by S1P1 receptors.
- -
-
Page/Page column 52
(2011/11/12)
-