- Method for preparing 4-bromo-2-methoxy-5-trifluoromethyl benzaldehyde
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The invention provides a method for preparing 4-bromo-2-methoxy-5-(trifluoromethyl) benzaldehyde, and belongs to the field of synthesis processes. The method comprises the following steps: carrying out formylation reaction on a compound VI, so as to obtain the 4-bromo-2-methoxy-5-trifluoromethyl benzaldehyde. The method for preparing the 4-bromine-2-methoxy-5-trifluoromethyl benzaldehyde has the advantages of easily available raw materials, mild reaction conditions, simple steps, low cost, safety, no toxicity and easiness in large-scale production, can obviously improve the total yield and purity of the target product 4-bromine-2-methoxy-5-trifluoromethyl benzaldehyde, and has wide application prospects.
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- PROCESS FOR THE PREPARATION OF THIOETHER-SUBSTITUTED AROMATIC KETONES
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The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds.
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- Process for the preparation of thioether-substituted aromatic ketones
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The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds.
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- A General Procedure for the Fluorodenitration of Aromatic Substrates
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The synthesis of several fluoroaromatic compounds by a new procedure of fluorodenitration of nitroarenes is reported.The methodology is based on the principle that the nitrite ion, generated during the fluorodenitration processes and responsible for most of the undesired side reactions, can be trapped with a suitable reagent, e.g., phthaloyl difluoride or tetrafluorophthaloyl difluoride.The yields of fluoro compounds thus obtained are good to excellent, and the procedure is of general application.
- Maggini, Michele,Passudetti, Margherita,Gonzales-Trueba, Guadalupe,Prato, Maurizio,Quintily, Ugo,Scorrano, Gianfranco
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p. 6406 - 6411
(2007/10/02)
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- Substituted diphenyl ethers
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A compound of the formula: STR1 and salts and esters thereof, useful as intermediates for the preparation of compounds of the formula STR2 wherein R1 is an alkyl group optionally substituted by one or more fluorine atoms or by an optionally substituted phenyl group R2 is No2 or Cl and R6 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms.
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