- Diarylmethylene disulfide compound as well as preparation method and application thereof
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The invention relates to the technical field of medicines and in particular relates to a diarylmethylene disulfide compound as well as a preparation method and application thereof. An experiment result shows that on a cell model, the diarylmethylene disulfide compound provided by the invention has an effect of inhibiting neurotoxicity caused by excessive glutamic acid and an effect of inhibiting neurotoxicity caused by hydrogen peroxide; the diarylmethylene disulfide compound also has a platelet aggregation resisting effect and can be used for reducing a cerebral infarct area in a mouse MCAO (Middle Cerebral Artery Occlusion) model. The results show that the diarylmethylene disulfide compound provided by the invention can have prevention and/or treatment effects on cerebral stroke.
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Paragraph 0055; 0056; 0057; 0058; 0059; 0105; 0106; 0107; 01
(2018/01/03)
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- The synthesis of symmetrical disulfides by reacting organic halides with Na2S2O3·5H2O in DMSO
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A one-pot, and scalable method to prepare symmetric disulfides from their corresponding primary, secondary, allylic, and benzylic halides has been developed. In this method, a disulfide is synthesized by reacting an alkyl halide with Na2S2O3·5H2O at 60-70 °C in DMSO.
- Abbasi, Mohammad,Mohammadizadeh, Mohammad Reza,Saeedi, Narges
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supporting information
p. 89 - 92
(2016/01/12)
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- Alternative Protocol for the Synthesis of Symmetrical Dibenzyl Diselenides and Disulfides
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A one-pot protocol for the preparation of symmetrical dibenzyl diselenides and disulfides from the corresponding benzyl alcohols employing NaBH2Se3 and NaBH2S3 as selenium-transfer and sulfur-transfer reagent, respectively, is described. Structurally diverse substituted benzyl alcohols afforded the corresponding diselenides and disulfides in good to excellent yields. The protocol is simple and mild, and the products were obtained within a short reaction time.
- Panduranga, Veladi,Prabhu, Girish,Panguluri, Nageswara Rao,Sureshbabu, Vommina V.
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p. 1711 - 1718
(2016/06/01)
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- Imidazole Promoted Highly Efficient Large-Scale Thiol-Free Synthesis of Symmetrical Disulfides in Aqueous Media
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A highly efficient and environmentally friendly method for the imidazole promoted preparation of symmetrical organic disulfides from Bunte salts is described. This thiol-free procedure produces the desired disulfides even on a large scale by reaction of Bunte salts with imidazole in good to high yields in aqueous media.
- Mokhtari, Babak,Kiasat, Ali Reza,Monjezi, Javid
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p. 1573 - 1579
(2015/09/15)
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- Deep eutectic mixture catalysed the synthesis of disulfides using Bunte salts as thiol surrogates
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Bunte salts, easily prepared from odourless sodium thiosulfates and various alkyl and aryl halides, acted as thiol surrogates for preparation of disulfides in the presence of hydrogen peroxide and a Bronsted-acidic deep eutectic mixture. The reaction proceeded smoothly to give the corresponding disulfide products in moderate to good yields, leaving odourless sodium bisulfite and water as the by-products. Moreover, this catalytic system could be readily recovered and reused several times without significant loss in activity.
- Zhou, Yongsheng
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p. 332 - 335
(2015/08/18)
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- The rapid and efficient synthesis of disulfides from alkyl and acyl halides
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Various symmetrical dialkyl and diacyl disulfides are prepared easily in high yields from the corresponding alkyl and acyl halides under mild and nonaqueous conditions using N,N'-dibutyl-N,N,N',N'-tetramethyl- ethylenediammonium tetrahydroborate (BTMETB) or N,N'-dibenzyl-N,N,N',N'- tetramethylethylenediammonium tetrahydroborate (BZTMETB) and elemental sulfur. The quaternary diammonium borohydrides were easily prepared by treatment of the corresponding quaternary diammonium chloride or bromide with alkaline solution of sodium borohydride at room temperature.
- Tajbakhsh, Mahmood,Lakouraj, Moslem M.,Mahalli, Majid S.
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experimental part
p. 1453 - 1456
(2009/12/04)
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- Electron transfer to sulfides and disulfides: Intrinsic barriers and relationship between heterogeneous and homogeneous electron-transfer kinetics
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The electron-acceptor properties of series of related sulfides and disulfides were investigated in N,N-dimethylformamide with homogeneous (redox catalysis) and/or heterogeneous (cyclic voltammetry and convolution analysis) electrochemical techniques. The electron-transfer rate constants were determined as a function of the reaction free energy and the corresponding intrinsic barriers were determined. The dependence of relevant thermodynamic and kinetic parameters on substituents was assessed. The kinetic data were also analyzed in relation to corresponding data pertaining to reduction of diaryl disulfides. All investigated reductions take place by stepwise dissociative electron transfer (DET) which causes cleavage of the Calkyl-S or S-S bond. A generalized picture of how the intrinsic electron-transfer barrier depends on molecular features, ring substituents, and the presence of spacers between the frangible bond and aromatic groups was established. The reduction mechanism was found to undergo a progressive (and now predictable) transition between common stepwise DET and DET proceeding through formation of loose radical anions. The intrinsic barriers were compared with available results for ET to several classes of dissociative- and nondissociative-type acceptors, and this led to verification that the heterogeneous and the homogeneous data correlate as predicted by the Hush theory.
- Meneses, Ana Belen,Antonello, Sabrina,Arevalo, Maria Carmen,Gonzalez, Concepcion Carmen,Sharma, Jadab,Wallette, Andrea N.,Workentin, Mark S.,Maran, Flavio
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p. 7983 - 7995
(2008/04/01)
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- Nitric Acid Mediated Oxidative Transformation of Thiols to Disulfides
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Oxidation of thiols to disulfides are reported using nitric acid/methylene chloride. Environmentally benign, economically convenient and simple reaction condition represents an attractive alternative to the existing approaches on both the laboratory and the industrial scale.
- Misra, Anup Kumar,Agnihotri, Geetanjali
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p. 1079 - 1085
(2007/10/03)
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- A novel reduction of sodium alkyl thiosulfates using samarium metal without an activating agent in water
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A novel metallic samarium promoted reduction of sodium alkyl thiosulfates in the absence of an activating agent occurs to afford the corresponding disulfides with good yields in water at 90°C.
- Wang, Lei,Li, Pinhua,Zhou, Li
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p. 8141 - 8143
(2007/10/03)
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- A rapid and efficient synthesis of symmetrical disulfides under microwave irradiation conditions
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A rapid and general method for the synthesis of symmetrical disulfides involves reaction of sulfur with sodium hydroxide under PTC-microwave irradiation condition to give sodium disulfide, which reacts with alkyl halides to afford the disulfides in good to excellent isolated yields.
- Wang, Jin-Xian,Gao, Lijuan,Huang, Danfeng
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p. 963 - 969
(2007/10/03)
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- Reduction of sulfur with borohydride exchange resin in methanol: Application to rapid and selective synthesis of disulfides
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A convenient and rapid method for the synthesis of symmetrical disulfides from alkyl or aryl alkyl halides using sulfurated borohydride exchange resin (SBER) under anhydrous conditions is described. Selective transfer of sulfur to an alkyl group rather than an aryl group is achieved using this methodology.
- Bandgar,Uppalla,Sadavarte
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p. 6741 - 6743
(2007/10/03)
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- Synthesis of novel mercapto analogues of Troger's base
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Synthesis of 2,8-bis(mercaptomethyl)-6H, 12H-5,11- methanodibenzo[b,f][1,5]diazocine (2) and its derivatization to 7 and 8 have been reported.
- Bag,Von Kiedrowski
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p. 1289 - 1290
(2007/10/03)
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- Reaction of carbon black with diazonium salts, resultant carbon black products and their uses
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Processes for coloring a fiber or textile by adding a carbon black product having an organic group attached to the carbon black. In one process at least one diazonium salt reacts with a carbon black in the absence of an externally applied electric current sufficient to reduce the diazonium salt. In another process at least one diazonium salt reacts with a carbon black in a protic reaction medium. Carbon black products which may be prepared according to process of the invention are described as well as uses of such carbon black products in plastic compositions, rubber compositions, paper compositions, and textile compositions.
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- 1-dethia-2-thia-cephalosporanic acids
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Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula STR1 wherein R is selected from the group consisting of STR2 Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted cycle or Rb NH--, Rb is optionally substituted carbocyclic or heterocyclic aryl, R1 and --COM are as defined in the specification, R4 is hydrogen or methoxy, n2 is 0, 1 or 2 and their non-toxic, pharmaceutically acceptable acid addition salts in racemic or optically active form having antibiotic activity and their preparation and novel intermediates.
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- A facile method for the syntheses of dialkyl disulfides from sulfur under phase transfer conditions
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A convenient reaction of alkyl halides with sulfur in alkaline medium has been found to afford disulfides in good to excellent isolated yield under phase transfer conditions.
- Wang,Cui,Hu
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p. 3573 - 3581
(2007/10/03)
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- Benzyltriethylammonium tetrathiomolybdate: An improved sulfur transfer reagent for the synthesis of disulfides
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Benzyltriethylammonium tetrathiomolybdate has been found to be a superior reagent for the conversion of alkyl halides to the corresponding disulfides in chloroform at room temperature.
- Ramesha,Chandrasekaran
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p. 3277 - 3284
(2007/10/02)
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- Novel Alkylation with Tetrathiotungstates and Tetrathiomolybdates: Facile Synthesis of Disulfides from Alkyl Halides
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A novel reaction of alkyl halides with piperidinium tetrathiotungstate or piperidinium tetrathiomolybdate (MS42-) has been found to afford disulfides in good to excellent isolated yields under very mild reaction conditions.
- Dhar, Preeti,Chandrasekaran, Srinivasan
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p. 2998 - 3000
(2007/10/02)
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- Transformation of Thiosulphonates into α-Sulphonyldisulphides, a New Class of Thioaldehyde Precursors
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Toluene-p-thiosulphonates, RCH2SSO2Tol (1) where R is an electron-withdrawing group, are transformed readily into α-sulphonyldisulphides (2) which, with triethylamine, undergo fragmentation-elimination to give 2 moles of thioaldehydes, RCHS.
- Kirby, Gordon W.,Lochead, Alistair W.,Sheldrake, Gary N.
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p. 1469 - 1470
(2007/10/02)
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