- Synthesis of [allyl-2,3-3H]-MN-9201
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Key step of the synthesis of calcium antagonist MN-9201 was the cyclizing addition of the ally-13-amino-crotonate onto methyl 2-[(3- nitrophenyl) methylene ]-3-oxobutanoate. It was then used to synthesize [Allyl-2,3-3H]-MN-9201 by the catalytic addition of tritium gas. Its radiochemical purity and specific activity were 98% and 2.1TBq/mmol, respectively.
- Wu, Dezhu,Huang, Wenlin,Wang, Wen,Mei, Qibing
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p. 785 - 789
(2007/10/03)
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- Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid
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Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acids as the active ingredient and methods of using same. The said ingredients are unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates which are substituted at position-4 of the dihydropyridine nucleus by phenyl which contains at least one nitro, cyano, azido, alkylthio, or alkylsulphonyl substituent. The compositions have a cardiovascular activity which makes them useful for effecting coronary vascular dilation and, also, they have utility in the treatment of hypertension.
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