The present invention relates to a novel process for the preparation of Pasireotide of formula 11 [Cyclo [Phe-{4-(OCO-NH-CH2-CH2-NH2)) Pro}-Phg-DTrp-Lys-Tyr(Bzl)]]. The invention also relates to a novel intermediate compound of formula 8 and process thereof which is used for preparation of compound of formula 11.
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Page/Page column 23
(2017/01/09)
A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential
A rational drug design approach, capitalizing on structure-activity relationships and involving transposition of functional groups from somatotropin release inhibitory factor (SRIF) into a reduced size cyclohexapeptide template, has led to the discovery o
Lewis, Ian,Bauer, Wilfried,Albert, Rainer,Chandramouli, Nagarajan,Pless, Janos,Weckbecker, Gisbert,Bruns, Christian
p. 2334 - 2344
(2007/10/03)
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