- Fluorinated Ketene Dithioacetals. 2. Synthesis of 2-Hydroperfluoro Acid Derivatives from Perfluoroketene Dithioacetals
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Perfluoroketene dithioacetals were prepared in high yields from perfluoroaldehyde hydrates via their thioacetalization (TiCl4/CH2Cl2) followed by basic phase transfer catalyzed HF elimination.Acidic hydrolysis (CF3CO2H, H2O) and then transesterification (EtOH, Ti(OiPr)4) yielded S-alkyl 2-hydroperfluoro thioesters and ethyl 2-hydroperfluoro esters, respectively.
- Muzard, Murielle,Portella, Charles
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- Synthesis method of 2,3,3,3-tetrafluoropropionate
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The invention belongs to the technical field of organic chemistry and provides a synthesis method of 2,3,3,3-tetrafluoropropionate. According to the synthesis method, a N,N-disubstituted-2,3,3,3-tetrafluoropropionamide pure product or a mixture containing 0.1 percent to 99.99 percent of the N,N-disubstituted-2,3,3,3-tetrafluoropropionamide is used as a starting raw material, and is hydrolyzed and treated by an esterification one-pot method in the presence of acid or alkali and corresponding alcohol to obtain the 2,3,3,3-tetrafluoropropionate. The 2,3,3,3-tetrafluoropropionate (II) is synthesized through adopting the simple and easy-to-operate one-pot method; an applicable range is wide and conditions are moderate; the synthesis method is suitable for industrial production.
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Paragraph 0033; 0034
(2017/02/17)
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- Fluorine gas for life science syntheses: Green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters
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Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.
- Harsanyi, Antal,Sandford, Graham
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supporting information
p. 3000 - 3009
(2015/05/27)
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- Synthesis and use of partially fluorinated dialkyl ethers derived from hexafluoropropylene
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A procedure was developed for preparing partially fluorinated dialkyl ethers by the reaction of hexafluoropropylene with aliphatic and polyfluorinated alcohols in the presence of KOH. On treatment with concentrated sulfuric acid, these ethers form alkyl esters of acids, and on treatment with KOH, alkenyl ethers.
- Il'in,Bakhmutov,Ivanova,Furin,Tolstikova,Sukhinin
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- Transformation de l'hexafluoropropene en alcool trifluoroallylique, precurseur des α-fluoroacrylates
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The fluoroacryloyl fluoride precursor of α-fluoroacrylic acid esters can arise from an allylic transposition of trifluoroallylic alcohol of which two methods of preparation are presented.In the first, dehydrofluoration of the alcohol CF3CFHCH2OH (4) is used.This alkohol is generated from the ester CF3CFHCOOC2H5 (3).In the second, dehalogenation of the alcohol CF3CFBrCH2OH (10) by zinc is used.The latter is formed by the selective reduction of the ester CF3CFBrCOOC2H5 (9). - Keywords: 2H-Tetrafluoropropanoic acid ester; 2H-Tetrafluoropropanol-1; Trifluoroallylic alcohol; α-Fluoroacryloyl fluoride; NMR spectroscopy
- Nguyen, Thoai,Wakselman, Claude
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p. 273 - 278
(2007/10/03)
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- FACILE SYNTHESIS OF DIALKYL FLUOROMALONATES AND THEIR DERIVATIVES
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Dimethyl and diethyl fluoromalonates were prepared by the stepwise basic alcoholysis of hexafluoropropene in a total yield of 50 - 55 percent.These dialkyl fluoromalonates were alkylated with alkyl halides, and the resulting dialkyl α-fluoroalkylmalonates were cyclized with urea affording 5-fluorobarbituric acid derivatives.
- Ishikawa, Nobuo,Takaoka, Akio
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p. 107 - 110
(2007/10/02)
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