- Utilities of olefin derivatives
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Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2-, —CY2═CZ2-, —CY2Y3—CHZ2-, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them; are disclosed.
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Page/Page column 13
(2008/06/13)
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- SYNTHESIS AND CHARACTERIZATION OF OXIMINO PYRIDOYL PHOSPHONATES
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Oximino pyridoyl phosphonates were synthesised as well as the methiodide of oximino-2-pyridoyl phosphonate.All these compounds along with their intermediates have been characterized by spectroscopic methods and by elemental analysis.Key words: Phosphite, Michaelis-Becker reaction, Oximino pyridoyl phosphonates.
- Kaushik, Mahabir P.,Vaidyanathaswamy, Ramamoorthy
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- A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES
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The Michaelis-Becker-Nylen reaction is well suited for the synthesis of 2-phosphonomethyl pyridines.We have improved this four steps method in a one pot reaction using commercial reagents.By this general procedure we have prepared seven new 2-phosphonomethyl pyridines (Ia-g) under mild conditions with higher yields.Key words: 2-phosphono pyridines; 2-phosphonomethyl pyridines; Michaelis-Becker-Nylen reaction; new phosphonates; potential ligands.
- Page, Patrick,Mazieres, Marie-Rose,Bellan, Jacques,Sanchez, Michel
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p. 205 - 210
(2007/10/02)
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- PHOTODEPHOSPHORYLATION OF PHOSPHONIC ACIDS
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Photolysis of phosphonic acids in an alkaline aqeous solution gave 1-benzyl-methylpyridinium phosphates by the photocleavage of the C-P bond.
- Okamoto, Yoshiki,Kokubu, Ichiro,Takamuku, Setsuo
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- Photolysis of Pyridylmethyl- and Pyridiniomethylphosphonic Acids
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Upon UV-irradiation, the C-P bond of (4-pyridylmethyl)phosphonic acid cleaved only near the isoelectronic point to give 4-methylpyridinium phophate, while (1-benzyl-4-pyridiniomethyl)phosphonic acid underwent C-P bond cleavage above pH 4 to give 1-benzyl-4-methylpyridinium phosphate.On the other hand, the C-P bond of (2-pyridylmethyl)phosphonic acid cleaved under pH region of about 1 to 2, while (1-benzyl-2-pyridiniomethyl)phosphonic acid underwent C-P bond cleavage above pH4.
- Okamoto, Yoshiki,Kokubo, Ichiro,Takamuku, Setsuo
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p. 2438 - 2440
(2007/10/02)
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