- A new method for making pyrazole or pyrimidinone
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The invention relates to the use of an amine compound in a method for producing a fluorinated or non-fluorinated 5- or 6-membered heterocyclic compound (preferably pyrazole or pyrimidinone) containingtwo nitrogen atoms in a ring system. The invention also relates to a method for producing a pyrazole or pyrimidinone, which may be fluorinated or may not be fluorinated (non-fluorinated). Each of thefluorinated pyrazole or fluorinated pyrimidinone is a very important structural unit for pharmaceutical and agricultural applications. For example, fungicides are strongly dependent on bifenapram, fluoxastrobin, flubenazolid, fluoxastrobin, pyraclostrobin, and pyracloprid, each with this fluorinated pyrazole as a key structural unit, and benflufenazole respectively, or diflufenacil and chlorfensulfazone (dimethachlor).
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Paragraph 0298-0301
(2019/11/28)
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- A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes
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Synthesis of a series of novel aryl and heteroaryl fused 2,8-dioxabicyclo[3.3.1]nonanes (3) was accomplished by one pot, catalyst free reaction of 2-hydroxy chalcone (1) with 3-trifluoromethyl substituted pyrazolone (2) in xylene at reflux temperature. Th
- Bingi, Chiranjeevi,Emmadi, Narender Reddy,Chennapuram, Madhu,Nanubolu, Jagadeesh Babu,Atmakur, Krishnaiah
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p. 35009 - 35016
(2014/11/07)
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- Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3- one nucleosides
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2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.
- Abdou, Ibrahim M.,Saleh, Ayman M.,Zohdi, Hussein F.
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p. 109 - 116
(2007/10/03)
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- STUDIES IN THE FIELD OF NITROGEN HETEROCYCLIC COMPOUNDS. PART XVI. A NOVEL "DIMROTH TYPE" REARRANGEMENT OF SOME 1-AMINO-2-PYRIDONE DERIVATIVES
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Condensation of β-ketoesters (1) with cynaoacetohydrazide (2) in alcoholic solutions of KOH leads to formation of potassium salts of the corresponding 1-amino-3-cyano-6-hydroxy-4-substituted 2-pyridones (3).It has been found that compounds 3i, j possessin
- Balicki, Roman
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