- PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS
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Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
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Page/Page column 0250; 0282
(2013/10/22)
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- Synthesis and evaluation of compounds that induce readthrough of premature termination codons
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A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.
- Jung, Michael E.,Ku, Jin-Mo,Du, Liutao,Hu, Hailiang,Gatti, Richard A.
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supporting information; experimental part
p. 5842 - 5848
(2011/10/18)
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- Gold catalysis: Switching the pathway of the furan-yne cyclization
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Changing tracks: By the use of alkynyl ethers as directing elements, the furan-yne cyclization enters a new reaction pathway. Instead of phenols, tetracycles containing two heteroatoms and two new stereocenters are formed (see scheme).
- Hashmi, A. Stephen K.,Rudolph, Matthias,Huck, Juergen,Frey, Wolfgang,Bats, Jan W.,Hamzic, Melissa
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supporting information; experimental part
p. 5848 - 5852
(2009/12/06)
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