SYNTHESIS OF 3,9-DIALKYLGUANINES AND THEIR CONVERSION INTO 3-ALKYLWYES, MODELS FOR THE FLUORESCENT NUCLEOSIDES FROM PHENYLALANINE TRANSFER RIBONUCLEIC ACIDS
Synthesis of 3,9-dialkylguanines 5 has been accomplished by N-cyanation of 1-alkyl-5-(alkylamino)imidazole-4-carboxamides 3 followed by base-catalysed cyclisation.Cyclocondensation of 9-alkyl-3-methylguanines 5a, d, f with MeCOCH2Br gave 3-alkylwyes 6, model compounds of the most probable structure for wyosine from Torulopsis utilis tRNAPhe.
Itaya, Taisuke,Ogawa, Kazuo
p. 1767 - 1774
(2007/10/02)
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