Synthesis of 1-substituted 5-aminoimidazole-4-carbaldehydes and 8-amino-1-(2-fluorobenzyl)imidazo[4′,5′:5,6]pyrido[2,3-d] pyrimidine
The syntheses of a number of 1-substituted 5-aminoimidazole-4-carbaldehydes 3, by the reduction of the corresponding 5-amino-4-cyanoimidazole derivatives is reported using LiAlH(OEt)3, prepared in situ from LiAlH4 and ethyl acetate. The compounds of type 1 are useful intermediates for the synthesis of elongated adenine derivatives.
Booth,Carpenter,Morlock,Mahmood,Pritchard
p. 2393 - 2396
(2007/10/03)
Facile synthesis of 6-cyano-9-substituted-9H-purines and their ring expansion to 8-(arylamino)-4-imino-3-methylpyrimidino-[5,4-d]pyrimidines
6-Cyano-9-substituted-9H-purines were prepared in a high yielding, one-step process by refluxing triethyl orthoformate or triethyl orthopropionate with the corresponding (Z)-N1-(aryl- or benzyl)-N2-(2-amino-1,2-dicyanovinyl)formamidi