Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity
5-Alkylidenepyridazin-3-ones with four points of diversity (R2, R6, X, Y) have been synthesized and evaluated as platelet aggregation inhibitors. Several derivatives eliciting antiplatelet activity in the low micromolar range (e.g.,
Pyridazines. Part 25: Efficient and selective deprotection of pharmacologically useful 2-MOM-pyridazinones using Lewis acids
An efficient and selective procedure for the cleavage of a methoxymethyl group at the 2-position in acid-sensitive pyridazinones is presented. Deprotection with Lewis acids (boron tribromide or aluminium chloride) affords 3(2H)-pyridazinones under mild co
Sotelo, Eddy,Coelho, Alberto,Ravi?a, Enrique
p. 8633 - 8636
(2007/10/03)
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