- An Interrupted Pummerer/Nickel-Catalysed Cross-Coupling Sequence
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An interrupted Pummerer/nickel-catalysed cross-coupling strategy has been developed and used in the elaboration of styrenes. The operationally simple method can be carried out as a one-pot process, involves the direct formation of stable alkenyl sulfonium salt intermediates, utilises a commercially available sulfoxide, catalyst, and ligand, operates at ambient temperature, accommodates sp-, sp2-, and sp3-hybridised organozinc coupling partners, and delivers functionalised styrene products in high yields over two steps. An interrupted Pummerer/cyclisation approach has also been used to access carbo- and heterocyclic alkenyl sulfonium salts for cross-coupling.
- Aukland, Miles H.,Talbot, Fabien J. T.,Fernández-Salas, José A.,Ball, Matthew,Pulis, Alexander P.,Procter, David J.
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p. 9785 - 9789
(2018/07/31)
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- STILBENE ANALOGS AND METHODS OF TREATING CANCER
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Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.
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Page/Page column 15
(2012/08/08)
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- Effects of substituent and solvent on the UV absorption energy of 4,4′-disubstituted stilbenes
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Twenty five samples of 4,4′-disubstituted stilbene derivatives were synthesized, and their UV absorption max wavelengths were determined in over 10 kinds of solvents including cyclohexane, ether, chloroform, acetonitrile and ethanol, in which 242 experimental data were recorded. The effects of substituents and solvents on the energy of their UV absorption max wavelengths were discussed. The research results showed: the energy of UV absorption max wavelengths of 4,4′-disubstituted stilbenes was mainly affected by their intramolecular structure (substituent effect) in a given solvent, that is, the energy is dominated by both of excited-state substituent parameter σ CC ex and polar substituent constant σ p. While their energy was dominated by the substituent effect and solvent effect in different kinds of solvents. An equation quantifying the energy of UV absorption max wavelengths of 4,4′-disubstituted stilbenes was developed. In addition, it is found that the n-octanol/water partition coefficient (logP) is more effective than the solvatochromic dye (E T(30)) in scaling the solvent effect. The equation employed the parameter logP has a better correlation and more specific physical meaning. Further, the energies of UV absorption max wavelengths of some reported compounds were predicted by the obtained equation, which are in agreement with their experimental values.
- Cao, Chenzhong,Chen, Guanfan,Wu, Yaxin
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scheme or table
p. 1735 - 1744
(2012/05/05)
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- Substituent effect on the UV spectra of p-disubstituted compounds XPh(CH=CHPh)nY (n=0, 1, 2)
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Three parameters, θCCex, θ CCex(XY) and Vmax,parent, are developed to express the substituent effect and the effect of the parent molecular structure of p-disubstituted compounds XPh(CH=CHPh)nY (n=0, 1, 2). The investigated result shows a good correlation between the UV absorption wavenumbers (Vmax) and the three parameters for a diverse set of title compounds, and the correlation equation can be used to predict the UV absorption energy of compounds with the mentioned structure. This approach provides a new insight for the quantitative structure-property relationship (QSPR) correlation of the UV absorption energy of p-disubstituted homologues. Copyright
- Chen, Guanfan,Cao, Chenzhong
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scheme or table
p. 776 - 782
(2011/05/05)
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- Radical fluoroarylation in radiochemical synthesis
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In this study, we report on the radical [18F]fluoroarylation of different olefins using 4-[18F]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[18F]fluoro substituted
- Hultsch, Christina,Blank, Olga,Wester, Hans-Jürgen,Heinrich, Markus R.
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p. 1881 - 1883
(2008/09/18)
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- Stilbene derivatives and their use for binding and imaging amyloid plaques
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This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting t
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- Electronic Structure and Free-Energy Relationships for Some 4'-Substituted 4-Dimethylamino trans-Stilbenes by U.V. Photoelectron Spectroscopy
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A series of 4'-substituted 4-dimethylamino trans-stilbenes 1-5 was investigated by UPS, in connection with conjugated donor-acceptor substituted double bond photochemistry.The measured and assigned spectra indicate a high sensitivity, depending on the changed electronic structure by 4'-substituents of compounds 1-5.Correlation of ionization energies in LFE-relationship with Hammett's ?p-values and other ground state data was proved, demonstrating UPS a powerful tool for substituent effect studies in conjugated double bond systems.
- Cauletti, C.,Furlani, C.,Palma, A.,Piancastelli, M. N.,Schleinitz, K. D.,Gloyna, D.
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p. 829 - 836
(2007/10/02)
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