- C-(β-d-Glucopyranosyl)formamidrazones, formic acid hydrazides and their transformations into 3-(β-d-glucopyranosyl)-5-substituted-1,2,4- triazoles: A synthetic and computational study
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Synthesis of O-perbenzoylated 3-(β-d-glucopyranosyl)-5-substituted-1, 2,4-triazoles, precursors of potent inhibitors of glycogen phosphorylase, was studied by ring closures of N1-acyl-carboxamidrazone type intermediates. Reactions of C-(β-d-glu
- Bokor, éva,Fekete, Attila,Varga, Gergely,Szocs, Béla,Czifrák, Katalin,Komáromi, István,Somsák, László
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p. 10391 - 10404
(2013/11/19)
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- A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles
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A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.
- Omodei-Sale, Amedeo,Consonni, Pietro,Galliani, Giulio
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p. 1187 - 1192
(2007/10/02)
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- Metallhydrazide, XIX. Addition bis(diethylaluminio)substituierter Amidrazone und Carbohydrazide an Nitrile
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Amidrazones and carbohydrazides react with two equivalents of triethylaluminium to give bis(diethylaluminio) derivatives 1 and 7, respectively.In contrast to the corresponding mono(diethylaluminio) derivatives or disodium salts, these are capable of addit
- Kauffmann, Thomas,Ban, Laszlo,Kuhlmann, Dieter
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p. 3684 - 3690
(2007/10/02)
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