- Hydroxylating Activity of a Water-soluble Manganese Porphyrin Associated with Potassium Hydrogen Persulfate: Formation of 8-hydroxyadenosine-5'-mono-phosphate from AMP.
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The associacion of potassium monopersulfate, KHSO5, with a wather-soluble manganese porphyrin complex has been recently reported as being a very efficient system for the oxidative cleavage of DNA (Fouquet et al., J.Chem.Soc., Chem.Commun., 1987, 1169); similar results are observed with RNA.As puzzle piece of the mechanism of this oxidative degradation of nucleic acids, we report in the present communications the identification of 8-hydroxyadenosine-5'-monophosphate as oxidation product of adenosine-5'-monophosphate (AMP) by KHSO5/(OAc)5.In the absense of manganese catalyst, the only detectable compound is the adenosine-N1-5'-monophosphate.
- Bernadou, Jean,Gelas, Pascale,Meunier, Bernard
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p. 6615 - 6618
(2007/10/02)
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