- CRYSTAL FORM OF TRICYCLIC COMPOUNDS AND APPLICATION THEREOF
-
本發明公開了式(I)所示化合物的A晶型及B晶型,及其在製備治療HBV相關疾病藥物中的應用。 The invention discloses “A”crystal form and“B”crystal form of a compound represented by formula (I) and an application thereof in a preparation of a medicament for treating HBV-related diseases.
- -
-
Paragraph 0039-0040; 0044-0045
(2020/09/18)
-
- Synthesis of 2-Alkylputrescines from 3-Alkylpyrroles
-
Acylation of 2-(trichloroacetyl)pyrrole gave the 4-acyl derivatives (from 4-formyl to 4-hexanoyl) in good yields.Alkaline treatment gave corresponding 4-acyl-2-pyrrolecarboxylic acids, were decarboxylated to the 3-acylpyrroles by prior conversion to the 3-acyl-2,4,5-triiodopyrroles followed by hydrogenolysis.The 3-acylpyrroles were reduced by treatment with hydrazine in alkaline medium to the 3-alkylpyrroles.The latter were ring-opened by treatment with hydroxylamine in the presence of bicarbonate to give the dioximes of the corresponding 2-alkylsuccinaldehydes, which were then reduced to the 2-alkylpurescines (1,4-diaminobutanes).Ring-opening of 2,3-dimethylpyrrole followed by reduction of the dioxime gave 1,2-dimethylputrescine; the same sequence gave 1,3-dimethylputrescine from 2,4-dimethylpyrrole, while 3,4-dimethylpyrrole did not ring-open and gave the dioxime of 3,4-dimethylmaleimide.
- Garrido, Daniel O. A.,Buldain, Graciela,Ojea, Maria I.,Frydman, Benjamin
-
p. 403 - 407
(2007/10/02)
-