- Preparation method of sun-screening agent 2-hydroxy-4-methoxy-5-sulfo benzophenone
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The invention provides a preparation method of a sun-screening agent 2-hydroxy-4-methoxy-5-sulfo benzophenone. According to the method, SO3 is used as a sulfonating agent, the process conditions are mild, the reaction process is easy to control, the product selectivity is good, byproducts are few, and the purification process is simple and feasible. Compared with a traditional process, the production of waste acid is greatly reduced, the water content in the product is greatly reduced, acidic impurities are reduced to a great extent, the product quality is further improved, and the method is agreen and environment-friendly process and is beneficial to industrial production.
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Paragraph 0052; 0054-0055
(2021/02/06)
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- Method for synthesizing BP-4 using microreactor
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The invention discloses a method for synthesizing BP-4 (2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid) using a micro-reactor. According to the method, 2-hydroxy-4-methoxy-benzophenone is taken as araw material, chlorosulfonic acid is taken as a sulfonating agent, reaction is carried out in a T-shaped liquid-liquid phase microreactor, and BP-4 is obtained. Compared with a traditional reactor, the microreactor possesses following characteristics: the flow scale and the dispersion scale of fluid in the micro-reactor is reduced by 1-2 orders of magnitudes, so that the micro-reactor has many excellent performances, and the introduction of micro-fluid enables the flow and transfer rules in the micro-reactor to change to a certain extent compared with the conventional equipment, thereby the mixing efficiency and reaction rate are increased. According to the method, 2-hydroxy-4-methoxy-benzophenone is used as an initial raw material, chlorosulfonic acid is used as a sulfonating agent, thereaction operation in the microreactor is simple, the reaction condition is mild, the selectivity and yield of products are high, the environmental pollution is small, and the method has a wide industrial development prospect.
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Paragraph 0031-0036
(2020/01/25)
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- Synthesis process for 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid
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The invention discloses a synthesis process for 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid. The process comprises the treatment flow: adding 2-hydroxy-4-methoxybenzophenone and a solvent into an enamel reaction kettle, dripping chlorosulfonic acid under the protection of nitrogen with stirring, controlling the temperature of the materials in the kettle to be 20-25 DEG C through jacket water bath cooling and control of the dripping speed of the chlorosulfonic acid, and performing a reaction for 20-25 h; performing centrifugal filtering separation on a product after reaction is finished, washing the product by using a corresponding solvent, and drying the product under the protection of the nitrogen; recycling a hydrogen chloride (HCl) byproduct in an HCl recycling packing tower in a water circulation mode to form a 20%-30% hydrochloric acid aqueous solution, and neutralizing a little hydrogen chloride gas of tail gas by using a solid alkali packing tower; and performing distillation recycling of the solvent by using an atmospheric distillation tower of a solvent distillation recycling system, and recycling 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid from raffinate at the bottom of the kettle.
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Paragraph 0011
(2016/11/28)
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- Cosmetic compositions
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Suggested is a cosmetic compositions comprising (a) a crosspolymer obtained from copolymerisation of at least two different polyols and at least one dicarboxylic acid and (b) at least one fragrance.
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- A composition for lightening skin and hair
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Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent.
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- Mineral/Organic Composite Material
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The invention relates to a composite material comprising nanoparticles of at least one metal derivative and at least one type of carboxylic and/or sulfonic acid derivative organic compound chemically bound in a covalent manner with said nanoparticles by means of at least one carboxylic and/or sulfonic function.
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- Use of Mineral/Organic Composite Material in the Form of an Ultraviolet Radiation Protective Agent
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The invention relates to the use of composite material which comprises nanoparticles of a least one metal derivative and at least one organic sunscreen agent which is chemically bound with said particles in a covalent manner in the form of an ultraviolet radiation protective agent containing the inventive composite material. Cosmetic ultraviolet radiation protective compositions comprises said mixture are also disclosed.
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- Benzoic acid ester compounds, compositions, uses and methods related thereto
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Benzoic acid ester compounds of formula (I): wherein R and R1-R5 are as defined in the description, methods for producing them and use thereof in cosmetic, pharmaceutical, personal care and industrial preparations as sunscreens based on photochemical precursor properties of ultraviolet absorbers.
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Page/Page column 17; 36
(2010/11/23)
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- SUNSCREEN COMPOSITIONS
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The present invention relates to improved sunscreen compositions, more preferably to improved sunscreen compositions containing at least one sunscreening agent (sunscreen) and a silicone-polyamide copolymer.
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- Structure-improving hair care agents
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There are provided topical hair care compositions for improving the structure and strength of hair keratin and the fastness to washing of hair colors which contain vitamin B6 derivatives of the formula (1) or physiologically compatible salts thereof.
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- Cosmetic skin-care product against ageing of the skin as an effect of light
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The present invention relates to a new cosmetic skin-care product for external use, which is based on UV-radiation-absorbing substances in combination with a free-radical scavenger system.
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- Cosmetic composition with photoprotective properties
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The invention is directed to a cosmetic composition with synergistically improved photoprotective properties, comprising at least one component selected from the group of Vitamin E, Vitamin C, derivatives of Vitamin E, derivatives of Vitamin C, and combinations of at least two of these components, and at least one natural polyamine or derivative.
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- Preparation of 4-alkoxy-2-hydroxybenzophenone-5-sulfonic acids
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4-alkoxy-2-hydroxybenzophenone-5-sulfonic acids of the general formula I STR1 where R1 is C1 -C20 -alkyl which is unsubstituted or substituted by halogen, cyanao, hydroxyl, C1 -C20 -alkoxy, C2 -C20 -alkoxycarbonyl, acyloxy and/or phenyl which is unsubstituted or substituted by C1 -c4 -alkyl, C1 -C4 -alkoxy and/or halogen, R2 and R3 independently of one another are each hydrogen, halogen, C1 -C12 -alkyl, C1 -C12 -alkoxy, C1 -C4 -haloalkyl, C3 -C8 -cycloalkyl, C4 -C12 -cycloalkylalkyl, cyano, hydroxyl or hydroxyethyl or are each phenoxy, C7 -C10 -phenalkyl or phenyl which is unsubstituted or substituted by C1 -C4 -alkyl, C1 -C4 -alkoxy and/or halogen, and R4 is hydrogen or sulfo, are prepared by reacting a 4-alkoxy-2-hydroxybenzophenone of the general formula II STR2 with chlorosulfonic acid at from -20° to +100° C., by a novel and improved process in which the reaction is carried out in an aliphatic, cycloaliphatic and/or aromatic carboxylate as solvent.
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