- Synthesis of the major metabolites of febuxostat
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Total synthesis of three Febuxostat metabolites, named 67M-1, 67M-2, and 67M-4,is described in this article. Through condensation of the key intermediate compound A with different side chains, and then oxidation and hydrolysis, we obtained three target compounds with an overall yield of 19.5%-28.0%.
- Li, Xiao Long,Qiu, Rui,Wan, Wei Li,Cheng, Xu,Hai, Li,Wu, Yong
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p. 217 - 221
(2015/06/23)
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