- Chemical compounds
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There are provided compounds of formula I, STR1 wherein R1, R2, R3, R4, R5 and R7 may be the same or different, and are hydrogen, hydroxy, alkoxy, alkoxy substituted by phenyl, acyl, amino, acylamino, alkenyl, halogen, or alkyl, provided that at least one of R1, R2, R3 and R7 are other than hydrogen and hydroxy, Or an adjacent pair of R1, R2, R3 and R7 represent a chain --COCH=CH--O--, X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, and E is a carboxy group or a tetrazole group, And pharmaceutically acceptable derivatives thereof. The compounds are indicated for use as antagonists of SRS-A.
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- Search for anxiolytic activity starting from a myorelaxant structure. tert Butylphenol derivatives
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Twenty eight compounds (10 phenoxypropanediols, 9 epoxides and 9 phenoxymethyloxazolidinones carrying on the benzene ring 1 or 2 tert. butyl groups and sometimes an allyl group) were investigated for myorelaxant and anxiolytic activities. These actions can be dissociated; 2 compounds - 5[(2 tert butylphenoxy)methyl]oxazolidin 2 one (R 1297) and 5 [(2 allyl 5 tert. butylphenoxy)methyl]oxazolidin 2 one (R 1377) - lack the former while being very effective in the 4 plate and electric battle tests. They have no sedative action and are virtually devoid of toxicity.
- Auzou,Rips,Derappe,Peyroux
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p. 548 - 554
(2007/10/07)
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