cas 409346-70-9, 6-BROMO-2-CHLORO-3-ETHYLQUINOLINE | Articles data ｜lookchem

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409346-70-9

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Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC50/s
Mabire, Dominique,Coupa, Sophie,Adelinet, Christophe,Poncelet, Alain,Simonnet, Yvan,Venet, Marc,Wouters, Ria,Lesage, Anne S. J.,Van Beijsterveldt, Ludy,Bischoff, Fran?ois
p. 2134 - 2153
(2007/10/03)

A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-Ethyl-2-[11C]methyl-6- quinolinyl)(cis-4-methoxycyclohexyl)methanone
A selective metabotropic glutamate 1 receptor (mGlu1) antagonist was labeled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studies and micro-positron emission tomography (micro-PET) imaging experiments in rats.
Huang, Yiyun,Narendran, Raj,Bischoff, Fran?ois,Guo, Ningning,Zhu, Zhihong,Bae, Sung-A.,Lesage, Anne S.,Laruelle, Marc
p. 5096 - 5099
(2007/10/03)

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Chemical Properties

Boiling Point: 345.5 °C at 760 mmHg
Flash Point:162.8 °C
Density: 1.522 g/cm³
Vapor Pressure: 0.000122mmHg at 25°C
Refractive Index: 1.643
PSA: 12.89000
LogP: 4.21310

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