- Catalyst-free aziridination and unexpected homologation of aziridines from imines
-
Aziridination and unpredicted homologation reaction of N-sulfonylimines were achieved easily with a very simple, rapid and mild procedure through the use of diazomethane without the presence of any catalyst. The method represents an attractive alternative
- Branco, Paula Serio,Raje, Vivek Prabhakar,Dourado, Jorge,Gordo, Joana
-
experimental part
p. 2968 - 2974
(2010/09/06)
-
- Solution-processable conjugated polymers containing alternating 1-alkyl-1,2,4-triazole and N=S=N links
-
Poly(sulfur nitride), [SN]x, is an infinite π-bonded system and only known polymeric superconductor composed of nonmetallic elements. The appealing electronic properties of [SN]x, along with the safety issue involved in the synthesis
- Wang, Mingfeng,Wudl, Fred
-
experimental part
p. 5659 - 5663
(2011/06/11)
-
- S-aminosulfeniminopenicillins: Multimode β-lactamase inhibitors and template structures for penicillin-based β-lactamase substrates as prodrugs
-
A series of novel penicillins, bearing an S-aminosulfenimine (R'(R'')NSN=) side chain at the 6-position, have been prepared by direct reaction of a penicillin ester with sulfur diimides. A set of these structures, with the thiazolidine-ring sulfur in the sulfide oxidation state, exhibited a pattern of reactivity not previously encountered in penicillin chemistry, viz., cleavage of the β-lactam ring resulted in a rapid intramolecular displacement of the S-amino moiety as R'(R'')NH. This was found to be the exclusive reaction occurring consequent on cleavage of the β-lactam ring. The mechanism of this process was delineated in a detailed study in basic methanol. That a similar reactivity pattern held for a penicillin salt in aqueous solution was also verified. Thus the salt 5bm (R' = CH3, R'' = p-CH3C6H4SO2) behaved as a moderate substrate for β- lactamase type I from Bacillus cereus (k(cat)/K(m) = 6.26 x 105 M-1 min- 1). On enzyme-catalyzed hydrolysis of this compound, displacement of N- methyl-p-toluenesulfonamide (R'(R'')NH) was directly observed (1H NMR) and found to occur faster than displacement of this group from (intact) 5bm in aqueous buffer, by a factor of at least 600. These findings identified the potential of the s-aminosulfeniminopenicillin structure type to be developed as β-lactamase substrates for use as site-specific-release prodrugs. A degree of enzyme inhibition was also observed with this set of thiazolidine- ring-sulfide structures with the most potent inhibitor having the most nucleofugic S-amino moiety p-ClC6H4SO2N(CH3), indicating that displacement of this group, at the enzyme active site, played a role in their mode of inhibition. Structures with the thiazolidine-ring sulfur in the sulfone oxidation state were considerably more potent as inhibitors, with the structure 5a2 being the most active. As this compound bore the least nucleofugic S-amino moiety C2H5OC(O)NH, it indicated that the mode of inhibition of the sulfones was distinct from that of the thiazolidine-ring sulfides; it is probable that the sulfones reacted in a manner similar to that shown by sulbactam viz., rapid scission of the thiazolidine-sulfone ring after cleavage of the β-lactam ring. Synergy of action was observed with 5a2 at high concentration (78 μg/mL) against Escherichia coli when combined 1:1 with penicillin G; no synergy was observed at low concentration (4 μg/mL) when combined with pipericillin, indicating poor permeation characteristics.
- Smyth, Timothy P.,O'Donnell, Michael E.,O'Connor, Michael J.,St Ledger, James O.
-
p. 7600 - 7618
(2007/10/03)
-
- Preparation and characterization of methyl 11-amino-(N-P-toluenesulfonyl)-9-E-octadecenoate and methyl 8-amino-(N-P-toluenesulfonyl)-9-E-octadecenoate
-
Allylic amination of methyl oleate with bis(N-p- toluenesulfonyl) sulfodiimide results in a mixture of methyl 11- amino-(N-p-toluenesulfonyl)-9-E-octadecenoate and methyl 8- amino-(N-p-toluerfesulfonyl)-9-E-octadecenoate in 58% yield. These novel products were isolated and characterized by nuclear magnetic resonance, infrared spectroscopy, mass spectrometry, and melting point. The reaction was analyzed by high- performance liquid chromatography and thin-layer chromatography.
- Herron, Barry F.,Bagby, Marvin O.,Isbell, Terry A.,Byrdwell, Wm Craig,Plattner, Ron,Weisleder, David
-
p. 229 - 234
(2007/10/03)
-
- An efficient preparation of optically active α-furfuryl amide by kinetic resolution using the modified Sharpless asymmetric epoxidation reagents
-
Kinetic resolution of α-furfuryl amide was first carried out by using the modified Sharpless asymmetric epoxidation reagent to give the slow-reacting enantiomers, (S)-1(a-h) and (R)-1(b,f) in high enantioselectivity (90-100% e.e) and high chemical yield (
- Zhou,Lu,Wang
-
p. 2641 - 2654
(2007/10/02)
-
- Chemistry of Reactive Cations Derived from Sulfur Dioxide Analogues, XIII. - Preparation and Cycloaddition Reactions of Cationic Sulfur Diimides
-
Two types of unsymmetrically substituted cationic sulfur diimides (1 and 2) have been synthestized.Diels-Alder reactions with 1 and 2 proceed regiospecifically in accordance with earlier hypotheses.
- Schwoebel, Alfred,Kresze, Guenter
-
p. 453 - 461
(2007/10/02)
-
- NEW FACILE SYNTHESIS OF N-SULFINYLAMINE DERIVATIVES USING N,N'-SULFINYLBISIMIDAZOLE AND N-(CHLOROSULFINYL)IMIDAZOLE
-
Treatment of amine derivatives such as amines, sulfonamides, and amides with N,N'-sulfinylbisimidazole (1) and N-(chlorosulfinyl)imidazole (2) in situ respectively gives the corresponding N-sulfinylamine derivatives (3): the latter reaction using N-(chlor
- Kim, Yong Hae,Shin, Jai Moo
-
p. 3821 - 3824
(2007/10/02)
-