Ruthenium-catalyzed direct amination of alcohols with tertiary amines
A highly selective phosphine-based ruthenium catalyst system efficiently catalyzes the direct amination of alcohols with aliphatic tertiary amines, yielding unsymmetric tertiary amines in yields up to 87%. Ligand and solvent both affect the reaction yields significantly. The reaction can be performed with a wide variety of functionalities.
Joint Synthesis of Tertiary Unsymmetrical and Symmetrical Aliphatic Amines
Tertiary unsymmetrical and symmetrical aliphatic amines were prepared by reaction of higher (C8-C16) and lower (C2-C4) aliphatic alcohols with nitriles containing the same number of carbon atoms as the lower aliphatic alcohols. Reaction conditions ensuring nearly quantitative yields of tertiary amines were determined.
Kozlov,Tereshko,Basalaeva,Tarasevich
p. 1095 - 1098
(2007/10/03)
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