- Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound
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Provided is an easy method (coupling method) capable of easily synthesizing a compound group in which aromatic molecules and aromatic molecules are coupled, a compound group in which aromatic molecules and alkene molecules are coupled, and the like without producing halogen waste and without the need to use scarce and expensive palladium. A compound (A) shown by general formula (A): Ar-H and a compound (B1) shown by general formula (B1): RaOCO-Ar', a compound (B2) shown by general formula (B2): RbCH=C(Ar")2, or a compound (B3) shown by general formula (B3): RcOCOCH=C(Ar")2 are reacted in the presence of a nickel compound.
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Paragraph 0271; 0275-0277; 0303-0305
(2020/09/17)
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- Nickel-catalyzed decarboxylative acylation of heteroarenes by sp 2 C-H functionalization
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Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, thro
- Yang, Ke,Zhang, Cheng,Wang, Peng,Zhang, Yan,Ge, Haibo
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supporting information
p. 7241 - 7244
(2014/06/23)
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- Nickel-catalyzed decarboxylative arylation of heteroarenes through sp2 C-H functionalization
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The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp2 C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aroma
- Yang, Ke,Wang, Peng,Zhang, Cheng,Kadi, Adnan A.,Fun, Hoong-Kun,Zhang, Yan,Lu, Hongjian
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supporting information
p. 7586 - 7589
(2015/04/22)
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- C-H alkenylation of azoles with enols and esters by nickel catalysis
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Rather u(Ni)que: Two new C-H alkenylation reactions, that is C-H/Ci£O alkenylation and decarbonylative C-H alkenylation, of azoles are uniquely catalyzed by Ni/dcype. These azole alkenylation reactions are successfully applied to the convergent formal synthesis of siphonazoleB.
- Meng, Lingkui,Kamada, Yuko,Muto, Kei,Yamaguchi, Junichiro,Itami, Kenichiro
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supporting information
p. 10048 - 10051
(2013/10/01)
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- Decarbonylative C-H coupling of azoles and aryl esters: Unprecedented nickel catalysis and application to the synthesis of muscoride A
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A nickel-catalyzed decarbonylative C-H biaryl coupling of azoles and aryl esters is described. The newly developed catalytic system does not require the use of expensive metal catalysts or silver- or copper-based stoichiometric oxidants. We have successfully applied this new C-H arylation reaction to a convergent formal synthesis of muscoride A.
- Amaike, Kazuma,Muto, Kei,Yamaguchi, Junichiro,Itami, Kenichiro
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supporting information; experimental part
p. 13573 - 13576
(2012/10/08)
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- Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives
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The first nickel-catalyzed C-H bond arylation of azoles with phenol derivatives is described. The new Ni(cod)2/dcype catalytic system is active for the coupling of various phenol derivatives such as esters, carbamates, carbonates, sulfamates, triflates, tosylates, and mesylates. With this C-H/C-O biaryl coupling, we synthesized a series of privileged 2-arylazoles, including biologically active alkaloids. Moreover, we demonstrated the utility of the present reaction for functionalizing estrone and quinine.
- Muto, Kei,Yamaguchi, Junichiro,Itami, Kenichiro
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supporting information; experimental part
p. 169 - 172
(2012/03/07)
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- Programmable oligomers for minor groove DNA recognition
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The four Watson-Crick base pairs of DNA can be distinguished in the minor groove by pairing side-by-side three five-membered aromatic carboxamides, imidazole (Im), pyrrole (Py), and hydroxypyrrole (Hp), four different ways. On the basis of the paradigm of
- Doss, Raymond M.,Marques, Michael A.,Foister, Shane,Chenoweth, David M.,Dervan, Peter B.
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p. 9074 - 9079
(2007/10/03)
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- N-H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles
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Dirhodium(II) carboxylate catalysed reaction of diazocarbonyl compounds 2 in the presence of primary amides 1 results in the formation of α-acylaminoketones 3 (12 examples) by N-H insertion reaction of the intermediate rhodium carbene. The 1,4-dicarbonyl
- Davies, James R.,Kane, Peter D.,Moody, Christopher J.
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p. 3967 - 3977
(2007/10/03)
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- Note on the Preparation of 5-Methyloxazole
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The title compound 4 was synthesized starting from methyl isocyanoacetate (1).
- Hoppe, Inga,Schoellkopf, Ulrich
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p. 819 - 820
(2007/10/02)
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