Metal-Free Amidation of Acids with Formamides and T3P
A new, simple and metal-free method for the direct formation of dialkylamides from carboxylic acids employing N,N-dialkylformamides as amine source is described. The one-pot reaction is promoted by propylphosphonic anhydride (T3P) in the presence of 0.5 equivalents of HCl.
Bannwart, Linda,Abele, Stefan,Tortoioli, Simone
p. 2069 - 2078
(2016/07/06)
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