- SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile
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(Chemical Equation Presented) A recyclable, convenient, and efficient catalytic system for C-acylation of 1,3-dicarbonyl compounds and malononitrile with acid chlorides has been developed, giving moderate to excellent yields under mild conditions. This is the first catalytic example of such reactions. In addition, by applying this protocol as the key step, 3,5-disubstituted-1H- pyrazole-4-carboxylate can easily be synthesized in high yields in a one-pot procedure.
- Shen, Quansheng,Huang, Wen,Wang, Jialiang,Zhou, Xigeng
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p. 4491 - 4494
(2008/03/12)
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- Synthesis and cyclization reaction of pyrazolin-5-one derivatives
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A versatile synthetic method for preparing 3-pyrazolin-5-ones and 5,8-dihydro-1H-pyrazolo[1,2-a]pyridazines from simple β-keto esters is demonstrated. The synthetic strategies involve the acylation of β-keto esters, cyclocondensation with hydrazine followed by trapping with a diene under oxidative conditions.
- Jung, Jae-Chul,Blake Watkins,Avery, Mitchell A.
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