Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.
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Page/Page column 8
(2008/06/13)
Efficient asymmetric hydrogenation of β- and γ-amino ketone derivatives leading to practical synthesis of fluoxetine and eprozinol
N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)me thyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphin o)methyl]pyrrolidine (BCPM)-rhodium(I) complexes were efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols.
Sakuraba,Achiwa
p. 748 - 753
(2007/10/02)
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