- Bile Acid Oligomers and Their Combination with Antibiotics to Combat Bacterial Infections
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The ever-growing risk of bacterial resistance is a critical concern. Among the various antimicrobial resistant bacterial strains, methicillin and vancomycin resistant Staphylococcus aureus are among the most dreadful, causing serious complications. On the basis of the hypothesis that microbes have reduced ability to develop resistance against membrane targeting antibiotics, bile acid oligomers having unique facially amphiphilic topologies were designed and synthesized. The oligomers with specific linkers exhibited potent and selective antibacterial activity against Gram-positive bacteria. The lead compounds also improved the efficacy of a range of known antibiotics belonging to different classes when tested in combination. The active dimers were found to be effective against antibiotic-resistant clinical isolates of S. aureus, including multidrug resistant isolates. A significant inhibitory activity against S. aureus biofilm, a highly drug-resistant bacterial phenotype often unresponsive to antibiotic therapy, was also noticed. No adverse effects were observed by these dimers in a cell viability assay against HEK293 cells.
- Singla, Poonam,Dalal, Priyanka,Kaur, Mahaldeep,Arya, Geeta,Nimesh, Surendra,Singh, Rachna,Salunke, Deepak B.
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p. 10265 - 10275
(2018/12/11)
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- Some imidazoline derivatives as corrosion inhibitors
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In this study, cationic surfactants having different alkyl chain lengths were prepared by amidation of lauric, myristic, palmitic, stearic, oleic acids with diethylene triamine. The products were quaternized using chlo-roacetic acid. The chemical structure of the prepared compounds was elucidated using different spectroscopic techniques. The critical micelle concentration (CMC) and the free energy of the micellization and adsorption of these compounds were determined by surface tension and conductivity measurements. The products were evaluated as surface-active agents as well as corrosion inhibitors for steel alloy in 1 M hydrochloric and sulfuric acid, the results indicate that these materials have a high efficiency as corrosion inhibitors and as surface active agents. These results were correlated with the chemical structure of the prepared compounds. AOCS 2009.
- Aiad, Ismail Abdelrhman,Hafiz,El-Awady,Habib
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experimental part
p. 247 - 254
(2011/12/02)
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