A Borrowing Hydrogen Strategy for Dehydrative Coupling of Aminoisoquinolines with Benzyl Alcohols in Water
We report a borrowing hydrogen strategy for a palladium-catalyzed dehydrative coupling of aminoisoquinolines with benzylic alcohols in water. This cascade reaction using the π-benzylpalladium system can be achieved in an atom-economic process without the
METHOD OF PREPARING 4-AMINO-1H-IMIDAZO(4,5-c)QUINOLINES AND ACID ADDITION SALTS THEREOF
The present invention provides a method of preparing a 4-(arylmethyl)amino-1H--imidazo(4,5-c)quinoline of formula (4) by reacting an arylmethylamine of formula (3) with a 4-chloro-lH-imidazo(4,5-c)quinoline of formula (2). The present invention further provides a method of preparing an acid addition salt of formula (5) comprising the step of hydrolyzing a 4-(arylmethyl)amino- 1 H-imidazo(4,5-c)quinoline of formula (4) with a strong acid, HX The present invention further provides a method of preparing a 4-amino- 1H-imidazo(4,5-c)quinoline of formula (1) comprising the step of treating an acid 10 addition salt of formula (5) with a base.
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Page/Page column 20-21
(2008/06/13)
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