- Antimycobacterial activity of ferutinin alone and in combination with antitubercular drugs against a rapidly growing surrogate of Mycobacterium tuberculosis
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The aim of this study was to investigate the antimycobacterial activity of the major daucane constituent, ferutinin (jaeschkeandiol p-hydroxybenzoate, 1), four of its natural analogues, its hydrolysis products, as well as methyl p-hydroxybenzoate (methylparaben) against Mycobacterium smegmatis, a rapidly growing surrogate of Mycobacterium tuberculosis. The agar dilution assay was utilised for an antimycobacterial evaluation of single compounds. A modified agar dilution assay, the checkerboard method, was utilised for evaluating the potentiating effect of 1 on different antitubercular drugs, namely isoniazid, ethionamide, rifampin and streptomycin. In the agar dilution assay, 1 exhibited higher potency (minimum inhibitory concentration [MIC] 10μgmL-1) than streptomycin and rifampin (MIC 20 μg mL-1 for each). Of the natural analogues, 8,9-epoxyjaeschkeandiol phydroxybenzoate and 8,9-epoxyjaeschkeandiol benzoate exhibited marginal activity (MIC ≥ 40 and 80μgmL-1, respectively). The checkerboard method showed that the combination of 1 with each antitubercular drug led to mutual enhancement of the antimycobacterial activity with isoniazid and ethionamide, while no such effect was observed with rifampin or streptomycin. Based on this study and earlier studies with Staphylococcus aureus, the major constituent 1 may be responsible for the major part of the antimicrobial activity of the root of Ferula hermonis.
- Abourashed, Ehab A.,Galal, Ahmed M.,Shibl, Atef M.
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- Synthesis and in vitro evaluation of ferutinol aryl esters for estrogenic activity and affinity toward cannabinoid receptors
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Ferutinin (1), the major constituent of Ferula hermonis and other Ferula species, is a sesquiterpene ester with remarkable estrogenic activity, beside other valuable medicinal properties. To investigate the influence of chemical modification of the feruti
- Osman, Ahmed M. Galal,Abourashed, Ehab A.,Slade, Desmond,Ahmed, Safwat A.,Gul, Waseem,Khan, Shabana I.,Elfadl, Tarek Abo,Dale, Olivia R.,Husni, Afeef S.,Cutler, Stephen J.,Elsohly, Mahmoud A.
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- PROSTANOIDS. LVIII. NEW α,ω-NORANALOGS OF PROSTAGLANDINS FROM FERUTINOL
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The chemical transformations of ferutinol aimed at the construction of structures that are of pharmacological interest were studied.
- Tolstikov, G. A.,Akbutina, F. A.,Dembitskii, A. D.,Valeev, F. A.,Miftakhov, M. S.
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p. 1666 - 1673
(2007/10/02)
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- SESQUITERPENOID ESTERS FROM THE FRUITS OF FERULA COMMUNIS
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The fruits of the toxic variety of Ferula communis gave a series of 1-oxojaeskeanadiol esters, whose structure was established by spectroscopic data and chemical reactions, including correlation with jaeskeanadiol.Treatment of these esters with potassium
- Appendino, Giovanni,Tagliapietra, Silvia,Paglino, Laura,Nano, Gian Mario,Monti, Diego,Picci, Vincenzo
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p. 1481 - 1484
(2007/10/02)
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