- COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
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The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
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Paragraph 0397
(2020/10/20)
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- Synthesis and electrogenerated chemiluminescence of donor-substituted phenylquinolinylethynes and phenylisoquinolinylethynes: Effect of positional isomerism
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In furtherance of our research on the design, synthesis and study of electrogenerated chemiluminescence (ECL) of new donor substituted phenylquinolinylethynes, we report here more new series with the aim of studying the effect of positional isomerism on their overall photophysical properties with a special focus on ECL. For this study we have chosen 2-, 3-, and 4-(p-substituted phenyl)ethynylquinolines, and 1- and 4-(p-substituted phenyl)ethynylisoquinolines. These ethynes were synthesized in good yields by modified Sonogashira coupling of the corresponding terminal alkyne with the respective haloquinolines. The photophysical properties and ECL were studied in acetonitrile solvent and the various results are discussed.
- Elangovan, Arumugasamy,Yang, Shu-Wen,Lin, Jui-Hsien,Kao, Kuo-Ming,Ho, Tong-Ing
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p. 1597 - 1602
(2007/10/03)
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- First synthesis and electrogenerated chemiluminescence of novel p-substituted phenyl-2-quinolinylethynes
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A series of p-substituted phenyl-2-quinolinylethynes as blue-green emitters were synthesized using a modified Sonogashira coupling reaction and their electrogenerated chemiluminescence properties are reported.
- Elangovan, Arumugasamy,Chen, Ting-Yu,Chen, Chih-Yuan,Ho, Tong-Ing
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p. 2146 - 2147
(2007/10/03)
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