cas 41889-45-6, BENZOYL NORECGONINE | Articles data ｜lookchem

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41889-45-6

Articles about 41889-45-6Total 1 be found

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Nonenzymatic hydrolysis of cocaine via intramolecular acid catalysis
The spontaneous hydrolysis of the methyl-ester group of cocaine (1) in vivo contributes to the metabolic clearance of the drug in man. Neighboring- group participation by the tropane N-atom of cocaine in this hydrolysis was suggested by the normal stability of the methyl-ester groups of pseudococaine and N-acylnorcocaine. For cocaine, the relative rate of methyl-ester to benzoyl-ester hydrolysis was ca. 10:1 at pH ≤ 7.4, and, although absolute rates increased with increasing pH, their ratio collapsed at pH > pK(a) (8.6). These data are consistent with intramolecular acid catalysis of alkaline hydrolysis of the cocaine methyl-ester group under physiologic conditions.
Li, Pan,Zhao, Kang,Deng, Shixian,Landry, Donald W.
p. 85 - 89
(1999)
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Findlay
p. 2855,2858, 2861
(1954)
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Kovacs et al.
(1956)
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More Articles about upstream products of 41889-45-6

Chemical Properties

Melting Point: 242 °C (decomp)
Boiling Point: 456.5°Cat760mmHg
Flash Point:229.9°C
Density: 1.32g/cm³
Storage Temp.:−20°C
Vapor Pressure: 3.98E-09mmHg at 25°C
PKA: 3.46±0.40(Predicted)
PSA: 75.63000
LogP: 1.76590

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