An indole-amide-based phosphine ligand enabling a general palladium-catalyzed sterically hindered Suzuki-Miyaura cross-coupling reaction
A novel family of indole-amide-based phosphine ligands was designed and synthesized. The Pd/InAm-phos (L1) catalytic system exhibited excellent efficiency in the Suzuki-Miyaura cross-coupling of sterically hindered (hetero)aryl chlorides to synthesize tri-ortho-substituted biaryls. Excellent product yields were obtained in a short reaction time (e.g., 10 min), and a Pd catalyst loading down to 50 ppm was also achieved. The oxidative addition adduct of Pd-L1 with 2-chlorotoluene was also well-characterized by single-crystal X-ray crystallography and showed a κ2-P,O-coordination of L1 with palladium.
Chen, Zicong,Ng, Shan Shan,So, Chau Ming,Yuen, On Ying
supporting information
p. 1373 - 1378
(2022/02/25)
Preparation of N,N-dimethyl aromatic amides from aromatic aldehydes with dimethylamine and iodine reagents
Various N,N-dimethyl aromatic amides were obtained in good to moderate yields by the reaction of aromatic aldehydes with aqueous dimethylamine in the presence of molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH) at room temperature. Under the same conditions and using the same procedure, treatment of aromatic aldehydes and morpholine in the presence of DIH also provided the corresponding N-aroyl morpholines in good to moderate yields. Georg Thieme Verlag Stuttgart · New York.
Baba, Haruka,Moriyama, Katsuhiko,Togo, Hideo
experimental part
p. 1175 - 1180
(2012/06/04)
Nucleophilic Addition of 2-Indolylacyl Anion Equivalents to N-Alkylpyridinium Salts
The reactions of the anions derived from dithioacetals 1-3 and α-amino nitriles 4 toward pyridinium salts 5 are studied.Depending on the nucleophile used, 2-(dihydropyridylmethyl)indoles 6 and 7, which can be cyclized to tetracyclic methanoazocinindole systems 10 and 11, respectively, or 2-substituted 3-(dihydropyridyl)indoles 8 and 9 are formed.
Bennasar, M.-Lluisa,Zulaica, Ester,Bosch, Joan
p. 2835 - 2841
(2007/10/02)
More Articles about upstream products of 41979-55-9