- Rate constants for hydrogen abstraction from alkoxides by a perfluoroalkyl radical. An oxyanion accelerated process
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A combination of laser flash photolysis and competitive kinetic methods has been used to measure the absolute bimolecular rate constants for hydrogen atom abstraction in water from a series of fluorinated alkoxides and aldehyde hydrates by the perfluoroalkyl radical, CF2CF2OCF 2CF2SO3-Na+. The bimolecular rate constants observed for the β-fluorinated alkoxides were in the 105 M-1 s-1 range, such rates representing enhancements (relative to the respective alcohols) of between 100 and almost 1000-fold, depending on the reactivity of the alkoxide. Likewise, the monobasic sodium salts of chloral and fluoral hydrate exhibit similar rate enhancements, relative to their respective hydrates.
- Cradlebaugh, Joseph A.,Zhang, Li,Shelton, G. Robert,Litwinienko, Grzegorz,Smart, Bruce E.,Ingold, Keith U.,Dolbier Jr., William R.
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- Brominated single walled carbon nanotubes as versatile precursors for covalent sidewall functionalization
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Herein we report on the facile preparation of brominated SWCNTs based on two complementary reductive activation routes. The respective brominated SWCNTs are highly reactive and can be used in nucleophilic substitution reactions and represent versatile starting materials for the generation of sidewall functionalized SWCNTs with a high density of functional moieties. This journal is the Partner Organisations 2014.
- Hof, Ferdinand,Hauke, Frank,Hirsch, Andreas
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- BORON CONTAINING COMPOUNDS AND THEIR USES
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The present disclosure contemplates novel boron-containing compounds and their uses as active agents that exhibit pesticidal activity such as antimicrobial, insecticidal, arachnicidal, and/or anti parasitic activity. An agrochemical composition containing such a compound and its use in, animal health, agriculture, or horticulture is also contemplated. A method for promoting plant performance and/or controlling, reducing, preventing, ameliorating, or inhibiting microbes, insects, arachnids, and/or parasites on or in an animal, a plant, a plant part, plant propagation material, and/or harvested fruits or vegetables is also contemplated.
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Paragraph 0299; 0200
(2020/03/29)
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- Phosphazene-derived stable and robust artificial SEI for protecting lithium anodes of Li-O2batteries
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A stable artificial solid electrolyte interphase (ASEI) containing phosphazene and perfluoroalkoxy groups was designed to protect Li anodes. The ASEI with high ionic conductivity and mechanicalrobustness successfully suppressed the growth of Li dendrites, significantly enhancing the electrochemical performance of the Li-O2 batteries.
- Bai, Wen-Long,Zhang, Zhen,Chen, Xin,Zhang, Qiang,Xu, Zhi-Xin,Zhai, Guang-Yao,Lin, Xiu,Liu, Xin,Tadesse Tsega, Tsegaye,Zhao, Chuan,Wang, Kai-Xue,Chen, Jie-Sheng
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supporting information
p. 12566 - 12569
(2020/11/02)
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- Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold
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Neutral sphingomyelinase 2 (nSMase2), a key enzyme in ceramide biosynthesis, is a new therapeutic target for the treatment of neurological disorders and cancer. Using 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol (DPTIP), our initial hit compound (IC50 = 30 nM) from nSMase2 screening efforts, as a molecular template, a series of 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol derivatives were designed, synthesized, and evaluated. Systematic examination of various regions of DPTIP identified the key pharmacophore required for potent nSMase2 inhibition as well as a number of compounds with the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold with similar or higher inhibitory potency against nSMase2 as compared to DPTIP. Among them, 4-(4,5-diisopropyl-1H-imidazol-2-yl)-2,6-dimethoxyphenol (25b) was found to be metabolically stable against P450 metabolism in liver microsomes and displayed higher plasma exposure following oral administration as compared to DPTIP. Analysis of plasma samples identified an O-glucuronide as the major metabolite. Blockade of the phase II metabolism should further facilitate our efforts to identify potent nSMase2 inhibitors with desirable ADME properties.
- Stepanek, Ondrej,Hin, Niyada,Thomas, Ajit G.,Dash, Ranjeet P.,Alt, Jesse,Rais, Rana,Rojas, Camilo,Slusher, Barbara S.,Tsukamoto, Takashi
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p. 276 - 289
(2019/03/28)
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- Compound having histone deacetylase-inhibiting activity, and pharmaceutical composition comprising the compound as an active ingredient
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A novel compound having histone deacetylase-inhibiting activity which is a cyclic tetrapeptide derivative represented by the general formula (1) given below and a pharmaceutical composition comprising such compound as an active ingredient. (In the formula, the cyclic tetrapeptide moiety has a known structure; R1 and R2 each independently represents an alkylene group containing 1 to 6 carbon atoms, which may be branched; X represents a group or bond selected from among —CO—, —O—, —S— or —SO—; Y represents a hydrogen or halogen atom, a phenyl group (including a substituted form), a pyridyl group (including a substituted form), an alkyl group (including a halogen-substituted form; hereinafter the same shall apply) containing 1 to 6 carbon atoms, an alkyloxy group containing 1 to 6 carbon atoms, an alkylcarbonyl group containing 1 to 6 carbon atoms, an alkyloxycarbonyl group containing 1 to 6 carbon atoms, an alkylthio group containing 1 to 6 carbon atoms, an alkylthiocarbonyl group containing 1 to 6 carbon atoms or a mono- or dialkylamino group containing 1 to 6 carbon atoms; when Y is a phenyl group (including a substituted form) or a pyridyl group (including a substituted form), it may form a further cyclic structure bound to R2.)
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- PROCESS FOR THE PREPARATION OF 3- AND 4-(PENTAFLUOROSULFANYL)BENZENES
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Process for the preparation of substituted 3- and 4-(pentafluorosulfanyI)benzenes of general formula 3 and 4 by nucleophilic aromatic substitution, where nitrobenzene having pentafiuorosulfanyl group connected in position 3 or 4 is allowed to react in concentration range 0.01 to 8.0 mol.l-1 with compound RY-M+, where R is selected from a group comprising saturated, unsaturated, acyclic, cyclic or aromatic, substituted or unsubstituted carbon chain, Y is the element of VI. B group and M+ is the metal ion, in an organic solvent. The invention includes also further chemical modifications of primary products.
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(2012/04/23)
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- INSECTICIDAL SUBSTITUTED AZINYL DERIVATIVES
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N-Azinyl-N′-aryl ureas and thioureas derivatives are effective at controlling insects.
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(2009/04/24)
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- DIHYDRO- 1H- PYRROLO [1,2-A] INDOL-1-YL CARBOXYLIC DERIVATIVES WHICH ACT AS S1P1 AGONISTS
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The present invention relates to certain (1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, sepsis, myocardial infarction, ischemic stroke, acne, microbial infections or diseases and viral infections or diseases.
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Page/Page column 65
(2009/09/05)
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- Isothiazole derivatives and processes for preparing the same as well as termite controlling agents comprising the same as active ingredient
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Isothiazole derivatives represented by general formula (I): wherein R, R1, Y and Z have the same significances as described in the specification, and processes for preparing the same as well as termite controlling agents comprising the same as active ingredient, are disclosed.
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- Heterocyclic compounds
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Novel insecticides of the formula STR1 in which n is 0 or 1, X is S, O, STR2 Y is N or STR3 Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R9 variously represent hydrogen or specified organic radicals.
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- Nitromethylene derivatives and their use as insecticides
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The present invention provides novel nitromethylene derivatives of the formula (I) STR1 wherein R represents a hydrogen atom or an alkyl group, X represents a haloalkyl, haloalkoxy, haloalkylthio, haloalkylsulfinyl, haloalkylsulfonyl, nitro, cyano, thiocyanato, haloalkenyl, haloalkynyl, hydroxyl, alkoxycarbonyl, amino, acyl, dialkylamino, acylamino or alkoxy group, l represents 1, 2 or 3 provided that when l is 1, X does not represent an alkoxy group and when l is 2 or 3, not all substituents X represent an alkoxy group, m represents 2, 3 or 4, and n represents 0 or 1, and the use of the new compounds as insecticides.
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- Phosphazene based functional fluid compositions
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A functional fluid composition is provided which comprises a plurality of different phosphazene compounds of the general formula (P=N)n(R)a(R')b(R'')c(R''')dwherein R is at least one alkoxy moiety described by the general formula -OCH2(CF2)yX, with X being hydrogen or fluorine and y being equal to 1 to about 10; R', R'' and R''' are different aryloxy moieties, each of R', R'' and R''' being selected from the group consisting of phenoxy, alkoxy phenoxys, alkyl phenoxys, chlorinated phenoxys, fluorinated phenoxys, aryl phenoxys, phenoxy phenoxys, fluoroalkyl phenoxys, fluoroalkoxy phenoxys, chlorinated phenoxy phenoxys, fluorinated phenoxy phenoxys and mixtures thereof; n is equal to 3 to about 4; for each of said phosphazene compounds, each of a, b, c and d is equal to or greater than zero such that the sum a+b+c+d is equal to 2n; and for the composition as a whole, the average value of each of a, b, c and d is greater than 0.
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- Aromatic Fluoroalkoxylation via Direct Aromatic Nucleophilic Substitution
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The reaction of activated aryl and heteroaryl halides with fluorinated alkoxide anions is described.In all cases, substitution of the halogen by a fluoroalkoxy group was observed.The effect of solvent, time, temperature, the activating group, leaving group, and the nucleophile on this reaction is also discussed.
- Idoux, John P.,Gupton, John T.,McCurry, Cynthia K.,Crews, A. Donald,Jurss, Cindy D.,et al.
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p. 3771 - 3773
(2007/10/02)
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- Novel Synthetic Reactions Using Bis(2,2,2-trifluoroethoxy)triphenylphosphorane
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Alkoxy-or (acyloxy)(2,2,2-trifluoroethoxy)triphenylphosphoranes which were prepared in situ by the ligand exchange of bis(2,2,2-trifluoroethoxy)triphenylphosphorane with alcohols or carboxylic acids were found to behave as potential alkylating or acylating reagents for the preparation of a variety of esters, amides, sulfides, and ketones.
- Kubota, Toshio,Miyashita, Satoshi,Kitazume, Tomoya,Ishikawa, Nobuo
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p. 5052 - 5057
(2007/10/02)
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