- N-Nitroheterocycles: Bench-Stable Organic Reagents for Catalytic Ipso-Nitration of Aryl- And Heteroarylboronic Acids
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Photocatalytic and metal-free protocols to access various aromatic and heteroaromatic nitro compounds through ipso-nitration of readily available boronic acid derivatives were developed using non-metal-based, bench-stable, and recyclable nitrating reagents. These methods are operationally simple, mild, regioselective, and possess excellent functional group compatibility, delivering desired products in up to 99% yield.
- Budinská, Alena,Katayev, Dmitry,Passera, Alessandro,Zhang, Kun
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supporting information
(2020/03/30)
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- A 2, 4, 5 - trifluoro -3 - chlorobenzoic acid preparation method
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The invention discloses a 2, 4, 5 - trifluoro - 3 - chlorobenzoic acid preparation method, which belongs to the chemical pharmaceutical intermediates preparation method technical field, the use of 1, 2, 4, - trifluorobenzene as raw materials, by nitration, chloro, re-nitration, reduction, diazotization, cyanide Sandmeyer reaction and hydrolysis reaction for preparing 2, 4, 5 - trifluoro - 3 - chlorobenzoic acid. The method of the invention, the raw materials using relatively inexpensive and easy to obtain, the process route is mature, the operation is simple, high yield, and has high industrial value.
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Paragraph 0016; 0020-0023
(2019/02/13)
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