Synthesis of a novel class of steroidal tetrazolo[1,5-a]pyridines via intramolecular 1,3-dipolar cycloadditions
A facile synthesis of a novel class of steroidal A/B/D-ring annulated tetrazolo[1,5-a]pyridine derivatives has been accomplished via intramolecular 1,3-dipolar cycloaddition reaction of azide with nitrile in aprotic solvent. The synthesis of D-ring annulated tetrazolo[1,5-a]pyridine in alcohol showed incorporation of an alcohol molecule into the heterocyclic system.
A Simple Acid-Catalyzed Isomerization of &γ-Hydroxy Enones into &γ-Diones
The acid-catalyzed isomerization of γ-hydroxy α,β-unsaturated ketones into γ-diones can be performed in high yields by using hydrogen bromide in ether.The utility of this functional group transformation is illustrated by its application to the synthesis of key intermediates 12a and 12b for rearranged drimanes, in steroid functionalization, and in the total synthesis of (+/-)-7-hydroxycostal.
Wijnberg, Joannes B. P. A.,Jongedijk, Gerard,Groot, Aede de
p. 2650 - 2654
(2007/10/02)
OXIDATION OF 3-ENOL DERIVATIVES OF 4-EN-3-OXO-STEROIDS BY TERT-BUTYL
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YASUDA
p. 1167 - 1174
(2007/10/07)
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