Cu-catalyzed aerobic oxidative three-component coupling route to N -sulfonyl amidines via an ynamine intermediate
Cu-catalyzed aerobic oxidative three-component coupling of a terminal alkyne, secondary amine, and sulfonamide enables efficient synthesis of amidines. The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupling products. Preliminary studies suggest that the reaction pathway involves initial oxidative coupling of the terminal alkyne with the secondary amine, followed by hydroamidation of the ynamine intermediate with the sulfonamide.
Kim, Jinho,Stahl, Shannon S.
p. 2448 - 2454
(2015/04/14)
DEFLUORINATIVE COUPLING REACTIONS OF gem-DIFLUOROOLEFINS WITH ORGANOLITHIUM REAGENTS. NOVEL, FACILE METHODS FOR CHAIN ELONGATIONS OF ALDEHYDES LEADING TO AMIDES, ACETYLENES, AND KETONES
Three types of coupling reactions of gem-difluoroolefins derived easily from aldehydes with lithium reagents (R'Li and R'2NLi) are described which constitute the facile procedures for conversions of aldehydes (RCHO) to amides (RCH2CONR'2), acetylenes (RCCR'), and ketones (RCH2COR').
Hayashi, Sei-ichi,Nakai, Takeshi,Ishikawa, Nobuo
p. 935 - 938
(2007/10/02)
More Articles about upstream products of 4231-26-9