An enantioselective synthesis of (S)-4-fluorohistidine
We report a new synthesis of enantiomerically pure (S)-4-fluorohisitidine based on diastereoselective alkylation of MOM-protected 4-fluoro-5-bromomethyl imidazole using the Sch?llkopf bis-lactim amino acid synthesis. Improvements in procedures for preparation of key intermediates are also described. (S)-4-Fluorohisitidine prepared by this new method was identical in all respects to material prepared by previous procedures.
Hajduch, Jan,Cramer, John C.,Kirk, Kenneth L.
experimental part
p. 807 - 810
(2009/04/11)
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