- C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE
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The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.
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Page/Page column 37
(2008/06/13)
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- Organoboranes for synthesis. 13. Simple, efficient syntheses of long-chain alcohols and carboxylic acids
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General, convenient and simple syntheses of long straight chain alcohols and carboxylic acids were developed utilizing organoborane chemistry. One of the methods entails the thermal isomerization of long-chain alkyldicyclohexylboranes, followed by oxidation. An alternative procedure for the preparation of long-chain alcohols involves the KAPA isomerization of internal alkynes to the terminal derivative, followed by dihydroboration with 9-BBN and oxidation. Alternatively, the terminal alkyne can be oxidised directly to the carboxylic acid. In another strategy, the C30-alcohol triaxontanol was prepared by employing high pressure carbonylation of a borane intermediate.
- Brown, Herbert C.,Iyer, Ramakrishnan R.,Bhat, Narayan G.,Racherla, Uday S.,Brown, Charles A.
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p. 9187 - 9194
(2007/10/02)
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- Photosensitive Monolayers. Photochemistry of Long-Chain Diazo and Azide Compounds at the Air-Water Interface
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The photochemistry of a number of surface-active diazo and azide compounds was investigated in monolayers at the air-water boundary.Irradiation of long-chain α-diazo ketones with ultraviolet light leads to rapid loss of nitrogen.The resulting ketenes react with the subphase to generate carboxylic acids (photochemical Arndt-Eistert reaction) and dimerize to give β-lactones as side-products.A long-chain diester of 2-diazopropanedioic acid loses nitrogen and adds water, yielding the diester of 2-hydroxypropanedioic acid. α-Azido ketones split off nitrogen and the resulting isocyanates react with water (photoche mical Curtius reaction) and undergo further degradation to give complex product mixtures.These reactions lead to pronounced changes in the spreading behavior of the monolayers.Depending on functional group, chain length, substrate pH, and temperature it is possible to achieve changes in compressibility and collapse pressure, disappearance of expanded phases, collapse of monolayers to give oily films, or disappearance of monolayers by dissolution in the subphase.
- Holden, David A.,Ringsdorf, Helmut,Haubs, Michael
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p. 4531 - 4536
(2007/10/02)
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