- Production method and system of naphthol AS series products
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The invention discloses a production method and system of naphthol AS series products. The specific steps are as follows: S1, taking chlorobenzene as a solvent for condensation reaction, dehydrating the chlorobenzene, adding the dehydrated chlorobenzene into a reactor, then adding raw material reactants of the naphthol AS series products, heating, raising the temperature, and dropwise adding phosphorus trichloride for condensation reaction; and S2, adding sodium carbonate and water into a distillation kettle, then introducing the condensed material in the S1 into the distillation kettle for heating and distilling, removing the solvent chlorobenzene, filtering the rest material, and carrying out flash evaporation drying on the filter cake to obtain the naphthol AS series products. The raw material reactants of the AS series products comprise a reactant A and a reactant B, wherein the reactant A is 2-hydroxy-3-naphthoic acid, and the reactant B can be o-aminophenetole, 2, 5-dimethoxy-4-chloroaniline, o-aminoanisole, parachloroaniline, o-toluidine, m-nitroaniline, menaphthylamine or 5-aminobenzimidazolone. Differentnaphthol AS series products can be obtained by selecting different reactants B according to needs.
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Paragraph 0021; 0024; 0030
(2021/08/28)
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- Method for preparing naphthol AS-LC by micro-channel continuous method (by machine translation)
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The method AS - LC of the present invention greatly shortens the reaction time, process, is easy to operate . has a high yield: high yield continuous production 2 - side reaction, and is especially, suitable for industrial production 2,5 - The method disclosed by the invention has the advantages 90-150 °C of simple process, easy operation, high yield, high, yield and, product quality. 20-80 s, The method disclosed by the invention comprises the following steps, a metering pump entering a microchannel reactor, and filtering in a microchannel reactor at, time, through water vapor distillation AS - LC. and washing, to obtain the color phenol, in a, micro-channel, reaction, through a metering pump in a micro-channel reactor, and the like. (by machine translation)
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Paragraph 0012; 0014-0015
(2020/05/30)
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- Novel preparation and processing technology of naphthol AS-LC
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The invention relates to a novel preparation and processing technology of naphthol AS-LC. The technology comprises the steps of carrying out a reaction in a separating type reaction kettle to obtain a crude product, and then purifying and drying the obtained crude product in a separating type dryer. The invention provides a novel, green and high-yield preparation technology and a simple processing and purification technology. After the method is used, water produced in the reaction process is effectively separated out, an amidation reaction is promoted to continuously move to the right in balance, and the product yield of the naphthol AS-LC is greatly improved by optimizing the reaction conditions. Furthermore, the product is further processed and purified by the novel dryer, so that the purity of the product is improved.
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Paragraph 0031-0038
(2017/03/14)
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- Fluorescent substrates for potential use in enzyme-linked immunosorbent assay of membrane-bound nucleic acids
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A number of phosphorylated fluorochromes were synthesized and tested for the alkaline phosphatase-linked fluorescence assay of membrane-bound nucleic acids. 3-Hydroxy-N-2′-biphenyl-2-naphthalenecarboxamide phosphate ester (HBNP) was found to be the most suitable for the assay. Nonfluorescent HBNP is hydrolyzed by phospholipase bound to the probe DNA to the highly fluorescent 3-hydroxy-N,2′-biphenyl-2-naphthalenecarboxamide (HBN). HBN is insoluble enough in aqueous medium to precipitate on the nylon membrane. Spots containing as little as 5 fg of λ DNA can be successfully detected on the membrane with HBNP.
- Fujita, Satoshi,Momiyama, Masayoshi,Kondo, Yasumitsu,Kagiyama, Naoto,Hori, Samuel H.,Toru, Takeshi
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p. 1347 - 1353
(2007/10/02)
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