- COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME AND ELECTRONIC DEVICE THEREOF
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The present invention provides a compound represented by Chemical Formula 1. Moreover, provided is an organic electric element including a first electrode, a second electrode, and an organic material layer between the first electrode and the second electrode, wherein the organic material layer includes the compound represented by Chemical Formula 1. When the compound represented by Chemical Formula 1 is included in the organic material layer of the organic electric element, a driving voltage is reduced, and light emitting efficiency, color purity, and lifecycle may be improved.(110) Substrate(120) Positive electrode(130) Hole injecting layer(140) Hole transporting layer(141) Buffer layer(150) Light-emitting layer(151) Light-emitting assisting layer(160) Electron transferring layer(170) Electron injecting layer(180) Negative electrodeCOPYRIGHT KIPO 2015
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Paragraph 0249-0252
(2016/10/08)
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- Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents
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New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate.
- Suryadevara, Praveen Kumar,Racherla, Kishore Kumar,Olepu, Srinivas,Norcross, Neil R.,Tatipaka, Hari Babu,Arif, Jennifer A.,Planer, Joseph D.,Lepesheva, Galina I.,Verlinde, Christophe L.M.J.,Buckner, Frederick S.,Gelb, Michael H.
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supporting information
p. 6492 - 6499
(2013/11/19)
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- PHENOXENIUM IONS. IDENTICAL INTERMEDIATES IN THE ACID-CATALYZED SOLVOLYSIS OF N-TOSYL-O-ARYLHYDROXYLAMINES AND IN THE THERMOLYSIS OF N-ARYLOXYPYRIDINIUM SALTS
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The acid-catalyzed solvolysis of N-tosyl-O-arylhydroxylamines in aromatic solvents and the thermolysis of N-aryloxypyridinium salts involve common intermediates, phenoxenium ions, for the formation of hydroxybiphenyl derivatives.Diphenylethers are formed when the heterolysis of the N-O bonds is slow and the aromatic solvent has high nucleophilicity.
- Iijima, Hiroyuki,Endo, Yasuyuki,Shudo, Koichi,Okamoto, Toshihiko
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p. 4981 - 4986
(2007/10/02)
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- Intramolecular Cyclization of Aryloxenium Ions. C-O-C and C-C Bond Formation. A Novel Ortho Effect
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o-Aryloxenium ions undergo intramolecular C-O-C bond formation readily as shown by the cyclizations yielding dibenzofurans. m-Aryloxenium ions cyclize via C-C bond formation provided the molecule can adopt the appropriate conformation for ring closure to occur.When an oxygen atom is ortho to the ?-aryl cation center, cyclization to form five- or six-membered rings does not occur and this is attributed to an interaction between oxygen and the positive charge that imposes an unfavorible conformation for cyclization on the aryloxy or arylalkyloxy side chain.
- Abramovitch, Rudolph A.,Bartnik, Romuald,Cooper, Melanie,Dassanayake, Nissanke L.,Hwang, Hang-Yuong,et al.
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p. 4817 - 4818
(2007/10/02)
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