- Reactions des radicaux 6-hydroxy-5,6-dihydrothymid-5-yles en solution aqueuse
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The main reactions of 6-hydroxy-5,6-dihydrothymid-5-yl radicals, specifically obtained by electron capture dissociation of the trans diastereomers of 5-bromo-6-hydroxy-5,6-dihydrothymidine, were determined in aqueous solutions on the basis of final product analysis.In oxygen-free aqueous solutions a complex mixture of both monomeric and dimeric decomposition products was produced.It is worth mentioning the radiation-induced formation of modified nucleosides which involves the transient generation of 5-(2'-deoxyuridyl)methyl radical.This may be explained in terms of initial formation of 6-hydroxy-5,6-dihydrothymid-5-yl radicals, followed by dehydration and subsequent deprotonation.
- Berger, M.,Sarrazin, F.,Cadet, J.
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p. 853 - 862
(2007/10/02)
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- Oxidation of Thymidine by Peroxymono- and Peroxodisulfate Ions
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Oxidation of thymidine by KHSO5 gave thymidine glycols, while a similar treatment with Na2S2O8 gave 5-hydroxymethyl-2'-deoxyuridine.
- Itahara, Toshio,Koga, Sunao
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